SkinSensPred as a Promising in Silico Tool for Integrated Testing Strategy on Skin Sensitization

Article Toxicology

Application of Defined Approaches for Skin Sensitization to Agrochemical Products

Judy Strickland et al.

Summary: The skin sensitization potential of agrochemical formulations can be evaluated effectively using non-animal test methods, with the KeratinoSens assay showing the best performance in predicting in vivo hazard outcomes. Defined approaches (DAs) that integrate data from multiple non-animal methods are accepted for hazard classification and potency categorization. However, further research and data generation are needed to improve the accuracy and reliability of these methods.

FRONTIERS IN TOXICOLOGY (2022)

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Article Chemistry, Medicinal

Pred-Skin: A Web Portal for Accurate Prediction of Human Skin Sensitizers

Joyce V. B. Borba et al.

Summary: Pred-Skin version 3.0 is a revised and expanded free web tool that predicts human skin sensitization potential using multiple QSAR models. The tool integrates various data sources and demonstrates relatively high accuracy in predicting human effects.

CHEMICAL RESEARCH IN TOXICOLOGY (2021)

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Review Pharmacology & Pharmacy

In silico Prediction of Skin Sensitization: Quo vadis?

Giang Huong Ta et al.

Summary: Direct skin contact with chemical or physical substances can lead to allergic contact dermatitis, and Europe has banned animal tests for safety evaluations of cosmetic ingredients. Various non-animal tests have been developed for safety assessment in both animal and non-animal models.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Evaluation of the Global Performance of Eight In Silico Skin Sensitization Models Using Human Data

Emily Golden et al.

Summary: This study evaluated eight in silico skin sensitization models against two human data sets and found that these models generally performed well in predicting human skin sensitization status, with approximately 70-80% accuracy. Combining different models may offer advantages, and while in silico models provide accurate and useful insights in a screening context, further improvements are needed for full reliability in regulatory applications.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2021)

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Article Toxicology