期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.972282
关键词
neurodegeneration; venous density; cognitive impairment; susceptibility weighted image (SWI); venous oxygenation
资金
- National Institute of Health (NIH)
- Alzheimer's Association
- [RF1 NS11041]
- [R01 NS108491]
- [R01 AG077422]
- [R13 AG067684]
- [P30 AG066512]
- [U24 EB028980]
- [AARG-17533484]
High-resolution susceptibility weighted imaging (SWI) can be a sensitive marker for characterizing cerebral oxygen metabolism and different stages of cognitive and functional status in neurodegenerative diseases, by quantifying white matter venous density and its associations with neurodegenerative features, WMHs, and clinical measures.
High-resolution susceptibility weighted imaging (SWI) provides unique contrast to small venous vasculature. The conspicuity of these mesoscopic veins, such as deep medullary veins in white matter, is subject to change from SWI venography when venous oxygenation in these veins is altered due to oxygenated blood susceptibility changes. The changes of visualization in small veins shows potential to depict regional changes of oxygen utilization and/or vascular density changes in the aging brain. The goal of this study was to use WM venous density to quantify small vein visibility in WM and investigate its relationship with neurodegenerative features, white matter hyperintensities (WMHs), and cognitive/functional status in elderly subjects (N = 137). WM venous density was significantly associated with neurodegeneration characterized by brain atrophy (beta = 0.046 +/- 0.01, p < 0.001), but no significant association was found between WM venous density and WMHs lesion load (p = 0.3963). Further analysis of clinical features revealed a negative trend of WM venous density with the sum-of-boxes of Clinical Dementia Rating and a significant association with category fluency (1-min animal naming). These results suggest that WM venous density on SWI can be used as a sensitive marker to characterize cerebral oxygen metabolism and different stages of cognitive and functional status in neurodegenerative diseases.
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