期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.974414
关键词
tau oligomers; exosomes; vesicles; misfolding; spreading; prion
This paper summarizes the novel findings of tau oligomers transmission and propagation via exosomes. Tau oligomers can be transferred from neuron to neuron, propagating through the brain and causing neurodegeneration, playing an important role in early-onset neurodegenerative pathogenesis.
The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered prion-like disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein into an abnormally folded aggregate. During the progression of the disease, misfolded tau polymerizes into oligomers and intracellular neurofibrillary tangles (NFTs). While the toxicity of NFTs is an ongoing debate, the contribution of tau oligomers to early onset neurodegenerative pathogenesis is accepted. Tau oligomers are readily transferred from neuron to neuron propagating through the brain inducing neurodegeneration. Recently, transmission of tau oligomers via exosomes is now proposed. There is still too much to uncover about tau misfolding and propagation. Here we summarize novel findings of tau oligomers transmission and propagation via exosomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据