4.7 Article

Biodegradable Carbon Dioxide-Derived Non-Viral Gene Vectors for Osteosarcoma Gene Therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Synthetic Conjugated Oligoelectrolytes Are Effective siRNA Transfection Carriers: Relevance to Pancreatic Cancer Gene Therapy

Chengbin Yang et al.

Summary: The conjugated oligoelectrolyte COE-S6 forms spherical nanoplexes with siRNA, which show protective effects, endosome escape, and transfection efficiencies comparable to commercial products. It can effectively silence the K-ras gene in pancreatic cancer cells, inhibit tumor growth, and has low toxicity. COE-S6-based nanoplexes have potential as nonviral vectors for gene delivery.

BIOMACROMOLECULES (2022)

Review Biochemistry & Molecular Biology

Organic/Inorganic Self-Assembled Hybrid Nano-Architectures for Cancer Therapy Applications

Chengbin Yang et al.

Summary: The translation: The field of nanomedicine has advanced into clinical trials, but drug formulations for cancer treatment still face limitations due to biological barriers. To overcome these challenges, organic/inorganic hybrids have been developed to integrate the benefits of both types of nanomaterials through a self-assembly approach.

MACROMOLECULAR BIOSCIENCE (2022)

Article Oncology

PLK1 inhibition-based combination therapies for cancer management

Shengqin Su et al.

Summary: This review discusses the role of PLK1 in cancer and the advantages of combining PLK1 inhibitors with other drugs for cancer treatment. PLK1 inhibitors in combination with chemotherapy drugs and targeted small molecules have shown superior effects against cancer both in vitro and in vivo. However, further research is needed to identify the best combination targets and drug combinations.

TRANSLATIONAL ONCOLOGY (2022)

Article Oncology

Osteosarcoma

Bree R. Eaton et al.

Summary: Osteosarcoma requires complex multidisciplinary management, with standard treatment involving chemotherapy and surgical resection, and radiotherapy used primarily for cases that cannot be surgically removed or for cases of incomplete resection.

PEDIATRIC BLOOD & CANCER (2021)

Review Genetics & Heredity

Review on mechanistic strategy of gene therapy in the treatment of disease

Sulaiman M. Alnasser

Summary: Gene therapy has revolutionized modern science with its rising advantages and limited negative aspects. The strategies of gene therapy mainly involve direct in-vivo gene delivery and ex-vivo genetically engineered stem cells.
Review Pharmacology & Pharmacy

The growth of siRNA-based therapeutics: Updated clinical studies

M. May Zhang et al.

Summary: After more than twenty years since the discovery of the natural gene-silencing mechanism of RNA interference, siRNA-based therapeutics have entered the pharmaceutical market with three approved drugs and many others in advanced stages of development. The majority of late-stage candidates are targeted towards rare diseases or patients who have not responded to current treatments, while some have potential for a wider patient population. This review provides an overview of siRNA mechanisms, barriers to delivery, and profiles of approved drugs and candidates in Phase 3 clinical trials.

BIOCHEMICAL PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

Polo-like kinase 1 (PLK1) signaling in cancer and beyond

Styliani Iliaki et al.

Summary: PLK1 is a Ser/Thr kinase that plays crucial roles in cell cycle regulation, DNA damage response, apoptosis, and cancer progression. Overexpression of PLK1 is associated with poor prognosis in cancer, making it an attractive therapeutic target.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Chemistry, Inorganic & Nuclear

Alternating Copolymerization of Carbon Dioxide with Epoxides Using Highly Active Dinuclear Nickel Complexes: Catalysis and Kinetics

Yu-Chia Su et al.

Summary: A novel series of dinuclear nickel complexes containing benzotriazole based 1,3-diamine-bisphenolate (1,3-DiBTP) ligands were synthesized as highly active single component catalysts for the copolymerization of CO2 and epoxides. The best benzoate-bonded dinickel catalyst demonstrated effective activity for CO2-copolymerization of cyclohexene oxide at high pressure and 1 atm, achieving a high turnover frequency and producing narrowly dispersed poly(cyclohexene carbonate) with high selectivity. Additionally, kinetic studies of the copolymerization process revealed first-order dependence on catalyst and epoxide concentrations, with an activation energy of 57.69 kJ mol(-1) for poly(cyclohexene carbonate) generation.

INORGANIC CHEMISTRY (2021)

Article Medicine, Research & Experimental

Intraperitoneal siRNA Nanoparticles for Augmentation of Gemcitabine Efficacy in the Treatment of Pancreatic Cancer

Siyuan Tang et al.

Summary: The study demonstrates that a combination of CXCR4 inhibition and PLK1 knockdown enhances the therapeutic effect of gemcitabine in an orthotopic model of metastatic pancreatic cancer. Nanoparticles containing cholesterol showed synergism in vitro, with the triple combination of PAMD-CHOL/siPLK1 and GEM exhibiting superior anticancer activity in vivo compared to single or dual combinations.

MOLECULAR PHARMACEUTICS (2021)

Review Medicine, General & Internal

New Horizons in the Treatment of Osteosarcoma

Paul S. Meltzer et al.

Summary: Osteosarcoma is a common malignant tumor that primarily affects individuals aged 10 to 30, and is usually treated with surgery and chemotherapy. While whole-genome sequencing can detect genetic alterations, it has not yet resulted in improved treatment outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Chemistry, Inorganic & Nuclear

Bimetallic Nickel Complexes Containing Benzotriazole-Derived Diamine-Bisphenolate Ligands as Highly Active Catalysts for the Copolymerization of Carbon Dioxide with Cyclohexene Oxide: Synthesis, Catalysis, and Kinetics

Wei-Fang Tsao et al.

Summary: In this study, a series of structurally well-defined dicarboxylate and dinitrate dinickel complexes were synthesized with ethyl N-substituted benzotriazole-containing diamine-bisphenolate derivatives as ligands. These complexes showed high catalytic activity for the copolymerization of CO2 with cyclohexene oxide, yielding CO2-based polycarbonates with controllable and immortal properties. The kinetics of the copolymerization process was systematically studied, revealing a first-order dependence on both the nickel catalyst and monomer concentrations.

ORGANOMETALLICS (2021)

Article Chemistry, Multidisciplinary

Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA

Chunhui Li et al.

Summary: The study synthesized a series of quaternary ammonium-based amphiphilic triblock polymers with a pH-sensitive hydrophobic core that can rapidly release internalized siRNA in endosomal pH environment, leading to enhanced gene silencing activity and significant therapeutic effects in tumor models.

NANO LETTERS (2021)

Article Multidisciplinary Sciences

An ionizable lipid toolbox for RNA delivery

Xuexiang Han et al.

Summary: In recent years, RNA therapeutics has seen significant growth, largely due to decades of research on lipid nanoparticles, particularly its key component - ionizable lipid. This commentary discusses the major types of ionizable lipids and offers perspectives for future development.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Osteosarcoma in Adolescents and Young Adults

Jun Ah Lee et al.

Summary: The study compared the clinical features and survival rates of osteosarcoma in adolescents and young adults (AYA) with other age groups. It found that AYA had the highest male-to-female ratio, with most tumors located in extremities. The treatment mainly consisted of local treatment and systemic chemotherapy, and the 5-year overall survival rate of AYA was closer to that of children.
Article Chemistry, Multidisciplinary

Polycation fluorination improves intraperitoneal siRNA delivery in metastatic pancreatic cancer

Yu Hang et al.

Summary: The study evaluated how the physicochemical properties of self-assembled polycation/siRNA nanoparticles affect their IP delivery efficacy in an orthotopic PDAC model. Fluorine-containing particles showed the best cell uptake and transfection efficacy, achieving the highest tumor accumulation in a PDAC model. Treatment with mPAMD-TFTA/siPLK1 demonstrated significant inhibition of both primary and metastatic PDAC tumors.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Environmental Sciences

Influence of particle size on the aggregation behavior of nanoparticles: Role of structural hydration layer

Hongyan Sun et al.

Summary: This study systematically evaluated the aggregation behavior of nano-silica particles and found that particle size has an impact on aggregation kinetics, with nanoparticles smaller than 190 nm not being describable by the Smoluchowski theory. The thickness of the structural hydration layer varied with particle size, leading to different aggregation behaviors.

JOURNAL OF ENVIRONMENTAL SCIENCES (2021)

Review Biochemistry & Molecular Biology

In Vivo Degradation Mechanisms of Aliphatic Polycarbonates and Functionalized Aliphatic Polycarbonates

Brian Amsden

Summary: This review examines the mechanisms by which aliphatic polycarbonates (APCs) and functionalized APCs degrade in vivo, aiming to provide guidance for the continued development of these polymers as biomaterials.

MACROMOLECULAR BIOSCIENCE (2021)

Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Chemistry, Multidisciplinary

Carbon Dioxide-Derived Biodegradable and Cationic Polycarbonates as a New siRNA Carrier for Gene Therapy in Pancreatic Cancer

Xinmeng Zhang et al.

Summary: The study highlights the potential of CPCHC-mediated siRNA therapies in treating pancreatic cancer by effectively silencing K-ras gene expression and inhibiting cell growth and migration. CPCHCs can protect siRNA from degradation, promote sustained endosomal escape, and induce cell apoptotic program in treated cancer cells.

NANOMATERIALS (2021)

Review Biology

siRNA therapeutics: a clinical reality

Phei Er Saw et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

Article Nanoscience & Nanotechnology

Folate-Mediated Targeted Delivery of siPLK1 by Leucine-Bearing Polyethylenimine

Lu Hou et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Pharmacology & Pharmacy

Comparison of cationic liposome and PAMAM dendrimer for delivery of anti-Plk1 siRNA in breast cancer treatment

Upendra Bulbake et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2020)

Review Biotechnology & Applied Microbiology

Immune Responses to Viral Gene Therapy Vectors

Jamie L. Shirley et al.

MOLECULAR THERAPY (2020)

Review Nanoscience & Nanotechnology

Polymer-mediated gene therapy: Recent advances and merging of delivery techniques

Janelle W. Salameh et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

Review Nanoscience & Nanotechnology

Biodegradable Polymers for Gene-Delivery Applications

Chih-Kuang Chen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Nanoscience & Nanotechnology

Combined Delivery of Temozolomide and siPLK1 Using Targeted Nanoparticles to Enhance Temozolomide Sensitivity in Glioma

Hui Shi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Polymer Science

Amphiphilic water soluble cationic ring opening metathesis copolymer as an antibacterial agent

Muhammad Nazrul Islam et al.

JOURNAL OF POLYMER SCIENCE (2020)

Review Biotechnology & Applied Microbiology

The current state and future directions of RNAi-based therapeutics

Ryan L. Setten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Chemistry, Multidisciplinary

Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery

Byungji Kim et al.

ADVANCED MATERIALS (2019)

Article Nanoscience & Nanotechnology

Biodegradable Polymer-Coated Multifunctional Graphene Quantum Dots for Light-Triggered Synergetic Therapy of Pancreatic Cancer

Chengbin Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Article Biotechnology & Applied Microbiology

Hampering brain tumor proliferation and migration using peptide nanofiber:siPLK1/MMP2 complexes

Mariarosa Mazza et al.

NANOMEDICINE (2019)

Review Pharmacology & Pharmacy

The proton sponge hypothesis: Fable or fact?

Lotte M. P. Vermeulen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Review Cell Biology

Regulating a key mitotic regulator, polo-like kinase 1 (PLK1)

Erica G. Colicino et al.

CYTOSKELETON (2018)

Article Nanoscience & Nanotechnology

pH-responsive hybrid nanoparticle with enhanced dissociation characteristic for siRNA delivery

Menghao Shi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Review Oncology

RNA interference-based therapy and its delivery systems

Xiuhui Chen et al.

CANCER AND METASTASIS REVIEWS (2018)

Article Biochemistry & Molecular Biology

Synthesis of Polylactide-Based Core-Shell Interface Cross-Linked Micelles for Anticancer Drug Delivery

Chih-Kuang Chen et al.

MACROMOLECULAR BIOSCIENCE (2017)

Review Biochemistry & Molecular Biology

Playing polo during mitosis: PLK1 takes the lead

G. Combes et al.

ONCOGENE (2017)

Review Pharmacology & Pharmacy

Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes

Chensu Wang et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Review Oncology

Cell cycle proteins as promising targets in cancer therapy

Tobias Otto et al.

NATURE REVIEWS CANCER (2017)

Article Nanoscience & Nanotechnology

Co-delivery of doxorubicin and recombinant plasmid pHSP70-Plk1-shRNA by bacterial magnetosomes for osteosarcoma therapy

Li Cheng et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

Article Materials Science, Biomaterials

Polymeric nanoparticles for targeted drug delivery system for cancer therapy

Farha Masood

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

Article Chemistry, Multidisciplinary

Antimicrobial activities of phosphonium containing polynorbornenes

N. Ceren Suer et al.

RSC ADVANCES (2016)

Article Pharmacology & Pharmacy

Polo-Like Kinase 1 as a Potential Therapeutic Target for Osteosarcoma

Li Cheng et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Article Chemistry, Analytical

Oligomeric Cationic Polymethacrylates: A Comparison of Methods for Determining Molecular Weight

Katherine E. S. Locock et al.

ANALYTICAL CHEMISTRY (2014)

Review Chemistry, Multidisciplinary

Advanced drug and gene delivery systems based on functional biodegradable polycarbonates and copolymers

Wei Chen et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Review Genetics & Heredity

Non-viral vectors for gene-based therapy

Hao Yin et al.

NATURE REVIEWS GENETICS (2014)

Article Polymer Science

Fully biodegradable antibacterial hydrogels via thiol-ene click chemistry

Hong Du et al.

POLYMER CHEMISTRY (2014)

Review Pharmacology & Pharmacy

Polymer gene delivery: overcoming the obstacles

Ahmed Aied et al.

DRUG DISCOVERY TODAY (2013)

Review Chemistry, Medicinal

Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents

Shanshan Li et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2013)

Article Chemistry, Physical

Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery

Jiangbing Zhou et al.

NATURE MATERIALS (2012)

News Item Chemistry, Physical

POLYMERS FOR GENE DELIVERY Charged for success

Enrico Mastrobattista et al.

NATURE MATERIALS (2012)

Article Chemistry, Physical

Poly(2,5-dihydroxy-1,4-benzoquinonyl sulfide) (PDBS) as a cathode material for lithium ion batteries

Kai Liu et al.

JOURNAL OF MATERIALS CHEMISTRY (2011)

Article Chemistry, Medicinal

Enhanced transfection of polyplexes based on pluronic-polypropylenimine dendrimer for gene transfer

Junguo Hao et al.

ARCHIVES OF PHARMACAL RESEARCH (2009)

Article Biochemistry & Molecular Biology

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo

Martin Steegmaier et al.

CURRENT BIOLOGY (2007)

Review Pharmacology & Pharmacy

Current status of polymeric gene delivery systems

Tae Gwan Park et al.

ADVANCED DRUG DELIVERY REVIEWS (2006)

Review Polymer Science

Characterization of synthetic polymers by MALDI-MS

G Montaudo et al.

PROGRESS IN POLYMER SCIENCE (2006)

Article Cell Biology

Active cyclin B1-Cdk1 first appears on centrosomes in prophase

M Jackman et al.

NATURE CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Plk1 promotes nuclear translocation of human Cdc25C during prophase

F Toyoshima-Morimoto et al.

EMBO REPORTS (2002)

Article Multidisciplinary Sciences

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

F Toyoshima-Morimoto et al.

NATURE (2001)

Article Biochemistry & Molecular Biology

Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents

HK Nguyen et al.

GENE THERAPY (2000)