期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-20361-x
关键词
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资金
- National Institute of Health [R01 NS093588, R37 NS035546, NS R01-NS093588S1, F31GM131677]
- National Research Foundation of Korea (NRF) - Korean government (MIST) [NRF-2022R1A2C1003766, NRF-2019M3C7A1031836]
- National Research Foundation of Korea [2019M3C7A1031836] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The balance between development and stress responses is crucial for the survival of organisms. However, the cellular signaling controlling this mechanism is not well understood. This study reveals a novel role for the N-terminal acetyltransferase C complex and histone deacetylase, in the control of animal development. These signaling proteins act, at least in part, through a PMK-1 p38 MAP kinase pathway, which plays a critical role in the innate immunity against infection.
Coordinating the balance between development and stress responses is critical for organismal survival. However, the cellular signaling controlling this mechanism is not well understood. In Caenorhabditis elegans, it has been hypothesized that a genetic network regulated by NIPI-3/Tibbles may control the balance between animal development and immune response. Using a nipi-3(0) lethality suppressor screen in C. elegans, we reveal a novel role for N-terminal acetyltransferase C complex natc-1/2/3 and histone deacetylase hda-4, in the control of animal development. These signaling proteins act, at least in part, through a PMK-1 p38 MAP kinase pathway (TIR-1-NSY-1-SEK-1-PMK-1), which plays a critical role in the innate immunity against infection. Additionally, using a transcriptional reporter of SEK-1, a signaling molecule within this p38 MAP kinase system that acts directly downstream of C/EBP bZip transcription factor CEBP-1, we find unexpected positive control of sek-1 transcription by SEK-1 along with several other p38 MAP kinase pathway components. Together, these data demonstrate a role for NIPI-3 regulators in animal development, operating, at least in part through a PMK-1 p38 MAPK pathway. Because the C. elegans p38 MAP kinase pathway is well known for its role in cellular stress responses, the novel biological components and mechanisms pertaining to development identified here may also contribute to the balance between stress response and development.
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