Tracking mutational semantics of SARS-CoV-2 genomes

Natural language processing (NLP) algorithms process linguistic data in order to discover the associated word semantics and develop models that can describe or even predict the latent meanings of the data. The applications of NLP become multi-fold while dealing with dynamic or temporally evolving datasets (e.g., historical literature). Biological datasets of genome-sequences are interesting since they are sequential as well as dynamic. Here we describe how SARS-CoV-2 genomes and mutations thereof can be processed using fundamental algorithms in NLP to reveal the characteristics and evolution of the virus. We demonstrate applicability of NLP in not only probing the temporal mutational signatures through dynamic topic modelling, but also in tracing the mutation-associations through tracing of semantic drift in genomic mutation records. Our approach also yields promising results in unfolding the mutational relevance to patient health status, thereby identifying putative signatures linked to known/highly speculated mutations of concern.

Automated summary

This article describes how natural language processing algorithms can be used to analyze the genomes and mutations of SARS-CoV-2, revealing its characteristics and evolution. The research found that NLP algorithms can not only study the temporal mutation features through dynamic topic modeling, but also track the semantic drift to understand the correlation of genomic mutations. In addition, this method is promising in uncovering the mutation relevance to patient health status.