期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-19806-0
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资金
- Korea Institute of Fusion Energy (KFE) - government of the Republic of Korea [EN2225-9]
- National Research Council of Science & Technology (NST) - Korea government (MSIT) [CRC-21021-300]
- National Research Council of Science & Technology (NST), Republic of Korea [EN2225] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study reported an efficient method for dimerization of EGCG, the major bioactive constituent isolated from tea leaves, using low-temperature plasma. The contribution of ozone in the reaction process was quantified as a major factor, and the mechanism of synthesizing dimers A and B through the generation of ozone and formaldehyde during plasma treatment was investigated.
The efficient dimerization of (-)-Epigallocatechin gallate (EGCG), which is the major bioactive constituent isolated from the leaves of Camellia sinensis, was initially reported without changes in its stereochemistry using low-temperature plasma. The contribution of plasma during the dimerization of EGCG in a methanolic solution was quantified using a major factor, with the major factor demonstrated based on the contents of newly generated products, in this case the sum of oolonghomobisflavans A and B depending on the plasma treatment method. Samples were treated in three methods: plasma direct treatment, an indirect treatment using only reactive species, and an indirect treatment using effects other than those by reactive species. Ozone was identified as a major factor during the plasma treatment, and the operating ranges of the ozone concentration for regulated dimerization were evaluated. The mechanism by which EGCG synthesizes dimers A and B during the treatment process using low-temperature plasma was investigated using the derived major factor and prior literature. The ozone generated by the plasma reacted with methanol to form formaldehyde, and dimers A and B were synthesized by oligomers through a methylene-bridge by the formaldehyde. A plausible pathway of regulated dimerization was deduced based on these results, and the mechanism of EGCG dimerization by plasma is described using this pathway.
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