Improved correspondence of fMRI visual field localizer data after cortex-based macroanatomical alignment

Studying the visual system with fMRI often requires using localizer paradigms to define regions of interest (ROIs). However, the considerable interindividual variability of the cerebral cortex represents a crucial confound for group-level analyses. Cortex-based alignment (CBA) techniques reliably reduce interindividual macroanatomical variability. Yet, their utility has not been assessed for visual field localizer paradigms, which map specific parts of the visual field within retinotopically organized visual areas. We evaluated CBA for an attention-enhanced visual field localizer, mapping homologous parts of each visual quadrant in 50 participants. We compared CBA with volume-based alignment and a surface-based analysis, which did not include macroanatomical alignment. CBA led to the strongest increase in the probability of activation overlap (up to 86%). At the group level, CBA led to the most consistent increase in ROI size while preserving vertical ROI symmetry. Overall, our results indicate that in addition to the increased signal-to-noise ratio of a surface-based analysis, macroanatomical alignment considerably improves statistical power. These findings confirm and extend the utility of CBA for the study of the visual system in the context of group analyses. CBA should be particularly relevant when studying neuropsychiatric disorders with abnormally increased interindividual macroanatomical variability.

Automated summary

The use of localizer paradigms to define regions of interest (ROIs) is important in studying the visual system with fMRI. However, the interindividual variability of the cerebral cortex poses challenges for group-level analyses. Cortex-based alignment (CBA) techniques have been shown to reduce this variability and improve statistical power. In this study, CBA was evaluated for visual field localizer paradigms, and the results confirmed its utility for studying the visual system in group analyses. CBA is particularly relevant for studying neuropsychiatric disorders with increased interindividual macroanatomical variability.