Usefulness of cortisol/ACTH ratio (CAR) for diagnosis of cushing's syndrome: comparison of CAR with findings in dexamethasone suppression test

Article Radiology, Nuclear Medicine & Medical Imaging

Investigation of Cushing's and subclinical Cushing's syndromes using adrenocortical scintigraphy

Yukinori Okada et al.

Summary: This study evaluated the factors influencing the intake rate of adrenocortical scintigraphy in Cushing's and subclinical Cushing's syndromes, and found that there were significant differences in intake rates between the two syndromes, allowing for differentiation based on intake rate.

NUCLEAR MEDICINE COMMUNICATIONS (2021)

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Review Endocrinology & Metabolism

Consensus on diagnosis and management of Cushing's disease: a guideline update

Maria Fleseriu et al.

Summary: Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management. The Pituitary Society convened a consensus workshop to discuss recent evidence and clinical practice. Recommendations regarding lab tests, imaging, and treatment options were collated and discussed, with focus on future research topics.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Article Medicine, General & Internal

Association Between Mortality and Levels of Autonomous Cortisol Secretion by Adrenal Incidentalomas A Cohort Study

Albin Kjellbom et al.

Summary: Autonomous cortisol secretion in patients with adrenal incidentalomas is positively correlated with mortality. The association between mortality and cortisol(DST) increases linearly until reaching 200 nmol/L. Further studies are recommended, and some clinicians may take these findings into consideration when determining which patients to recommend for surgery.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Medical Laboratory Technology

Yield of Serum Dexamethasone Measurement for Reducing False-Positive Results of Low-Dose Dexamethasone Suppression Testing

Stephen M. Roper

Summary: The measurement of serum dexamethasone following the low-dose dexamethasone suppression test can help reduce false positive results caused by low dexamethasone bioavailability or medication noncompliance. This approach is practical and affordable for improving the accuracy of detecting Cushing syndrome.

JOURNAL OF APPLIED LABORATORY MEDICINE (2021)

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Article Endocrinology & Metabolism