Transfontanelle photoacoustic imaging for in-vivo cerebral oxygenation measurement

The capability of photoacoustic (PA) imaging to measure oxygen saturation through a fontanelle has been demonstrated in large animals in-vivo. We called this method, transfontanelle photoacoustic imaging (TFPAI). A surgically induced 2.5 cm diameter cranial window was created in an adult sheep skull to model the human anterior fontanelle. The performance of the TFPAI has been evaluated by comparing the PA-based predicted results against the gold standard of blood gas analyzer measurements.

Automated summary

The capability of measuring oxygen saturation through a fontanelle using transfontanelle photoacoustic imaging (TFPAI) has been demonstrated in large animals. The performance of TFPAI was evaluated by comparing the predicted results with the gold standard of blood gas analyzer measurements.