期刊
NUTRIENTS
卷 14, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/nu14204350
关键词
diet; sucrose; estrous cycle; sex hormone; estrogen; progesterone; gonadotropin
This study explores the relationships between diet, sex hormone concentrations, and the estrous cycle, which are important for understanding infertility and estrogen-dependent diseases. The findings indicate that both the amount and pattern of dietary sucrose intake affect the estrous cycle and sex hormone concentrations in female rats.
Relationships between diet, sex hormone concentrations, and the estrous cycle are important from the perspective of infertility and estrogen-dependent disease prevention and treatment. Four dietary interventions reflecting modern eating behaviors were explored. The study involved 50 female rats divided into five feeding groups. The impact of the amount of sucrose consumed (9% and 18% of the dietary energy content), alternating high-sucrose and sucrose-free diets, and a high-sucrose diet combined with intermittent one-day fasting on the estrous cycle and sex hormone concentrations in female rats was assessed. Even low amounts of dietary sucrose (9% of the dietary energy content) were found to lead to increased estradiol (E2) concentrations and decreased progesterone (Pg) concentrations. A high-sucrose diet, even when periodically applied, additionally led to a reduced concentration of luteinizing hormone (LH). The largest changes in the hormones tested were observed with one-day fasting coupled with the high-sucrose diet; in addition, the estrous phase was shortened and the estrous cycle was disrupted. The results of this study show that both the amount of dietary sucrose and also its uptake pattern affect the estrous cycle and sex hormone concentrations in female rats.
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