期刊
NUTRIENTS
卷 14, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/nu14163385
关键词
coronary artery calcification; pericardial adiposity; Mediterranean-Style Dietary Pattern Score
资金
- National Institutes of Health National Heart, Lung, and Blood Institute [R01 HL61753, R01 HL079611, R01 HL113029]
- American Diabetes Association [7-06-CVD-28]
- American Diabetes Association Grant [7-13-CE-02, 7-13-CD-10]
- Diabetes Endocrinology Research Center Clinical Investigation Core [P30 DK57516]
- Diabetes Research Center Core [P30-DK116073]
- NIH/NCATS Colorado CTSA [UL1TR002535]
- NIH [M01 RR000051]
This case-control study using baseline data shows a significant association between a Mediterranean dietary pattern and lower volume of pericardial adiposity, providing evidence of its association with lower cardiovascular risk markers.
Several studies have identified improvements in the risks of cardiovascular disease in adults following a Mediterranean dietary pattern. However, data are scarce on its association with coronary artery calcification (CAC) and pericardial adiposity (PAT) in US adults with and without diabetes. To address this gap, we conducted a case-control study using baseline data from the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study [n = 1255; Type 1 Diabetes (T1D): n = 563; non-Diabetes Mellitus (non-DM): n = 692]. Participants completed a validated food frequency questionnaire, fasting (12 h overnight fast) biochemical analyses, and a physical examination including anthropometric measures. CAC and PAT were measured using electron beam-computed tomography. Logistic regression models were used to examine the associations of the Mediterranean-Style Dietary Pattern Score (MSDPS) with CAC (presence or absence), and linear regression models were applied to PAT analyses. In all of the adjusted models, no significant associations with CAC were found. For PAT, an increasing MSDPS was consistently associated with its lower volume in models adjusted for age, sex, diabetes status, total calories, and body mass index (all p < 0.05). The association between MSDPS and PAT was attenuated after adjusting for serum lipids and physical activity. In conclusion, the baseline data from the CACTI study show that a greater adherence to MSDPS is associated with a lower PAT volume and provide evidence that the Mediterranean dietary pattern is associated with lower cardiovascular risk markers.
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