期刊
NUTRIENTS
卷 14, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/nu14193968
关键词
exercise training; paraventricular nucleus; hypertension; angiotensin II type 1 receptor; MAPK
资金
- National Natural Science Foundation of China [81500313, 82170451, 82070440, 82070439]
- Research Programof Xi'an Children's Hospital [2020A02]
The study indicated that aerobic exercise training may decrease blood pressure in hypertensive rats by down-regulating the AT-1R in the PVN through the ROS/MAPK/NF-kappa B pathway, ultimately ameliorating 2K1C-induced hypertension.
Background: Aerobic exercise training (ExT) is beneficial for hypertension, however, its central mechanisms in improving hypertension remain unclear. Since the importance of the up-regulation of angiotensin II type 1 receptor (AT-1R) in the paraventricular nucleus (PVN) of the hypothalamic in sympathoexcitation and hypertension has been shown, we testified the hypothesis that aerobic ExT decreases blood pressure in hypertensive rats by down-regulating the AT-1R through reactive oxygen species (ROS)/mitogen-activated protein kinase (MAPK)/nuclear factors kappa B (NF-kappa B) pathway within the PVN. Methods: Forty-eight male Sprague-Dawley (SD) rats were assigned to the following groups: sham operation (SHAM) + kept sedentary (Sed), SHAM + exercise training (ExT), two kidney-one clamp (2K1C) + Sed, and 2K1C + ExT groups. Results: The 2K1C + Sed hypertensive rats showed higher systolic blood pressure (SBP), upregulated ROS, phosphorylated (p-) p44/42 MAPK, p-p38 MAPK, NF-kappa B p65 activity, and AT-1R expression in the PVN, and increased circulating norepinephrine (NE) than those of SHAM rats. After eight weeks of aerobic ExT, the 2K1C + ExT hypertensive rats showed attenuated NE and SBP levels, suppressed NF-kappa B p65 activity, and reduced expression of ROS, p-p44/42 MAPK, p-p38 MAPK, and AT-1R in the PVN, relatively to the 2K1C + Sed group. Conclusions: These data are suggestive of beneficial effects of aerobic ExT in decreasing SBP in hypertensive rats, via down-regulating the ROS/MAPK/NF-kappa B pathway that targets AT-1R in the PVN, and eventually ameliorating 2K1C-induced hypertension.
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