4.7 Article

α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration

期刊

NUTRIENTS
卷 14, 期 18, 页码 -

出版社

MDPI
DOI: 10.3390/nu14183717

关键词

vitamin E; carboxyethyl hydroxy chromanol (CEHC); stable isotope-labeled vitamin E

资金

  1. UC Davis Center for Health and Nutrition Research Program
  2. NIH UCD Clinical and Translational Sciences Center [UL1 TR001860]
  3. Cystic Fibrosis Foundation
  4. Linus Pauling Institute
  5. Oregon State University Foundation fund
  6. NSERC [155187]

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This study investigated the absorption and plasma concentration of tocopherol in patients with cystic fibrosis (CF) after vitamin C supplementation. The results showed that vitamin C supplementation increased the concentration of alpha-tocopherol and decreased its disappearance rate. Therefore, vitamin C supplementation may have positive effects in CF patients.
Background: Numerous abnormalities in cystic fibrosis (CF) could influence tocopherol absorption, transportation, storage, metabolism and excretion. We hypothesized that the oxidative distress due to inflammation in CF increases vitamin E utilization, which could be positively influenced by supplemental vitamin C administration. Methods: Immediately before and after receiving vitamin C (500 mg) twice daily for 3.5 weeks, adult CF patients (n = 6) with moderately advanced respiratory tract (RT) disease consumed a standardized breakfast with 30% fat and a capsule containing 50 mg each hexadeuterium (d(6))-alpha- and dideuterium (d(2))-gamma-tocopheryl acetates. Blood samples were taken frequently up to 72 h; plasma tocopherol pharmacokinetics were determined. During both trials, d(6)-alpha- and d(2)-gamma-tocopherols were similarly absorbed and reached similar maximal plasma concentrations similar to 18-20 h. As predicted, during vitamin C supplementation, the rates of plasma d(6)-alpha-tocopherol decline were significantly slower. Conclusions: The vitamin C-induced decrease in the plasma disappearance rate of alpha-tocopherol suggests that vitamin C recycled alpha-tocopherol, thereby augmenting its concentrations. We conclude that some attention should be paid to plasma ascorbic acid concentrations in CF patients, particularly to those individuals with more advanced RT inflammatory disease and including those with severe exacerbations.

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