期刊
NUTRIENTS
卷 14, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/nu14183776
关键词
sunlight; micronutrient; calcium; vitamin D supplements; serum vitamin D; low back; pain treatment; pain intensity; longitudinal; elderly
资金
- Instituto de Salud Carlos III, State Secretary of R+D+I
- FEDER/FSE [16/1512, 18/287, 19/319, 20/00896, PI22/01111]
- REACT EU Program (Comunidad de Madrid) (FACINGLCOVID-CM project)
- REACT EU Program (European Regional Development Fund-ERDF. European Union) (FACINGLCOVID-CM project)
- Universidad Autonoma de Madrid
- Spanish Ministry of Science, Innovation, and Universities [RYC-2018-025069-I]
The study found that increased dietary vitamin D intake is associated with lower pain incidence and favorable pain changes over 5 years in older adults.
Background: Vitamin D plays a role in bone health, pain signaling, and inflammation. We examined the largely unknown relation of dietary vitamin D intake with pain incidence and pain changes over time in older adults. Methods: Data were taken from the Seniors-ENRICA-1 cohort, which included 950 individuals aged >= 60 years. Habitual vitamin D intake was assessed in 2012 with a validated diet history, and pain both in 2012 and 2017 with a scale ranging from 0 (no pain) to 6 (highest pain), according to its severity, frequency, and number of locations. Analyses on pain incidence and pain changes were performed in the 524 participants free of pain at baseline and the overall sample, respectively. Results: Higher dietary vitamin D intake was associated with lower 5-year pain incidence; the multivariable-adjusted odds ratio (95% confidence interval) was 0.88 (0.79,0.99) for every 1-mu g/day increase in vitamin D intake, and 0.49 (0.28,0.88) for the highest (>3.52 mu g/day) vs. lowest (<1.85 mu g/day) tertile. Dietary vitamin D intake (highest vs. lowest tertile) was also associated with 5-year favorable pain changes: the multivariable-adjusted odds ratio of pain worsening vs. no change/pain improvement was 0.55 (0.36,0.86), and the beta coefficient for changes in the pain scale was -0.56 (-1.03,-0.09). Similar results were found for pain severity, frequency, and number of pain locations. Conclusions: In an older adult population, where compliance with vitamin D intake recommendations was very low, a slightly increased dietary intake was associated with lower pain incidence and favorable pain changes over 5 years.
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