期刊
NUTRIENTS
卷 14, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/nu14173648
关键词
breast milk; bioactive protein; proteomic analysis; lactation periods
资金
- National Natural Science Foundation Program of China [32130081]
- 111 project of the Education Ministry of China [B18053]
- Major Science and Technology Special Project of Hohhot City
Breast milk is essential for infants as it provides the necessary nutrients and acquired immunity in the first month. The composition of breast milk protein varies with lactation stage, with colostrum containing the most characteristic proteins. The protein expression in breast milk undergoes significant changes between day 3 and day 14 and stabilizes after 14 days.
Breast milk is an unparalleled food for infants, as it can meet almost all of their nutritional needs. Breast milk in the first month is an important source of acquired immunity. However, breast milk protein may vary with the stage of lactation. Therefore, the aim of this study was to use a data-independent acquisition approach to determine the differences in the proteins of breast milk during different lactation periods. The study samples were colostrum (3-6 days), transitional milk (7-14 days), and mature milk (15-29 days). The results identified a total of 2085 different proteins, and colostrum contained the most characteristic proteins. Protein expression was affected by the lactation stage. The proteins expressed in breast milk changed greatly between day 3 and day 14 and gradually stabilized after 14 days. The expression levels of lactoferrin, immunoglobulin, and clusterin were the highest in colostrum. CTP synthase 1, C-type lectin domain family 19 member A, secretoglobin family 3A member 2, trefoil factor 3 (TFF3), and tenascin were also the highest in colostrum. This study provides further insights into the protein composition of breast milk and the necessary support for the design and production of infant formula.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据