期刊
NEUROSCIENCE BULLETIN
卷 38, 期 11, 页码 1315-1329出版社
SPRINGER
DOI: 10.1007/s12264-022-00930-w
关键词
Zona incerta; GABAergic neurons; Whole-brain connectome; Input circuit; Output circuit; Topological connection
资金
- National Natural Science Foundation of China [61890953, 31871088]
- Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2019-I2M-5-014]
- Wuhan National Laboratory for Optoelectronics
This study comprehensively mapped the long-range connectivity of different sectors in the mouse ZI using fluorescence micro-optical sectioning tomography and viral tracing techniques. The results show that the input-output circuits of ZI GABAergic neurons are topologically organized, and the medial and lateral ZI are two different major functional compartments.
The zona incerta (ZI) is involved in various functions and may serve as an integrative node of the circuits for global behavioral modulation. However, the long-range connectivity of different sectors in the mouse ZI has not been comprehensively mapped. Here, we obtained whole-brain images of the input and output connections via fluorescence micro-optical sectioning tomography and viral tracing. The principal regions in the input-output circuits of ZI GABAergic neurons were topologically organized. The 3D distribution of cortical inputs showed rostro-caudal correspondence with different ZI sectors, while the projection fibers from ZI sectors were longitudinally organized in the superior colliculus. Clustering results show that the medial and lateral ZI are two different major functional compartments, and they can be further divided into more subdomains based on projection and input connectivity. This study provides a comprehensive anatomical foundation for understanding how the ZI is involved in integrating different information, conveying motivational states, and modulating global behaviors.
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