Physically and chemically crosslinked hydrogels for wound healing applications

Article Engineering, Biomedical

Preparation, mechanical properties, fatigue and tribological behavior of double crosslinked high strength hydrogel

Weichao Li et al.

Summary: A novel high-performance PVA hydrogel enhanced by chemical double crosslinking (CDC) method was synthesized, which showed over 600% elongation at break, reduced modulus loss after fatigue test by 42%, decreased average coefficient during friction to 0.048, and excellent biocompatibility. This PVA hydrogel enhanced by CDC method provides a new concept for preparing high-performance PVA hydrogel and serves as a promising material to replace cartilage, meniscus, nucleus pulposus, and other tissues.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2022)

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Review Pharmacology & Pharmacy

Strategies and Therapies for Wound Healing: A Review

Hitesh Chopra et al.

Summary: This article discusses the critical factors and challenges in wound healing, and explores the use of biopolymers as a treatment solution.

CURRENT DRUG TARGETS (2022)

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Article Chemistry, Applied

Multifunctional polysaccharide hydrogels for skin wound healing prepared by photoinitiator-free crosslinking

Hongli Mao et al.

Summary: This study developed a polysaccharide-based hydrogel dressing with excellent properties, which accelerated wound healing and improved skin regeneration through in situ photocrosslinking.

CARBOHYDRATE POLYMERS (2022)

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Letter Surgery

Wound dressings: Recent updates

Hitesh Chopra et al.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Article Polymer Science

Preparation and Evaluation of Chitosan/PVA Based Hydrogel Films Loaded with Honey for Wound Healing Application

Hitesh Chopra et al.

Summary: In this study, chitosan/polyvinyl alcohol (PVA)-based hydrogel films loaded with honey were developed for potential wound healing applications. The films were evaluated for their physical and mechanical properties, as well as their antimicrobial performance against Staphylococcus aureus. The results demonstrated the potential of these films as wound dressings and suggested the need for further in vivo experiments to evaluate their clinical efficacy.

GELS (2022)

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Review Pharmacology & Pharmacy

Biopolymer-based Scaffolds for Tissue Engineering Applications

Hitesh Chopra et al.

Summary: Tissue engineering involves the use of cells and polymers, with natural polymers offering advantages over synthetic ones. Various targeted drug delivery systems have been developed using polymers and cells, and dermal substitutes aim to replace skin parts either through grafting or other methods.

CURRENT DRUG TARGETS (2021)

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Review Engineering, Biomedical

Recent advances on polymeric hydrogels as wound dressings

Zheng Pan et al.

Summary: Hydrogels are attracting intensive attention for their high porosity, good biocompatibility, and beneficial properties for wound healing. Traditional hemostasis methods have limitations, while hydrogel dressings offer more advantages. Future research and development should focus on overcoming the challenges of hydrogel dressings and improving their performance and applications.

APL BIOENGINEERING (2021)

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Review Materials Science, Biomaterials