Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer

Article Nutrition & Dietetics

Association of plant-based diet index with prostate cancer risk

Stacy Loeb et al.

Summary: This study suggests that consuming a greater amount of healthful plant-based foods is associated with a reduced risk of aggressive forms of prostate cancer, with a stronger effect observed among men under 65 years of age.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)

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Review Oncology

Methionine Restriction: Ready for Prime Time in the Cancer Clinic?

Jun Yamamoto et al.

Summary: Efforts to selectively starve cancer cells have been made for a century. Calorie-restriction or low-carbohydrate diets have limited success. Methionine restriction, especially in combination with chemotherapy, has shown promising results in preclinical studies. The question remains whether methionine restriction, either through diet or with the help of methioninase, is ready for clinical use, particularly for advanced cancer patients.

ANTICANCER RESEARCH (2022)

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Review Medicine, Research & Experimental

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

Sebastian J. Hofer et al.

Summary: Age-associated diseases are on the rise, leading to a need for efficient and low-cost methods. Caloric restriction (CR) is effective but implementation can be challenging, giving rise to CR-mimicking interventions. The advantages and disadvantages of these dietary interventions in humans must be carefully considered.

EMBO MOLECULAR MEDICINE (2022)

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Article Dermatology

Nicotinamide Attenuates UV-Induced Stress Damage in Human Primary Keratinocytes from Cancerization Fields

Lara Camillo et al.

Summary: Nicotinamide (NAM) has protective effects against UV-induced oxidative stress and inflammation in skin cells.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Nutrition & Dietetics

Multivitamin Use and Overall and Site-Specific Cancer Risks in the National Institutes of Health-AARP Diet and Health Study

Jung-Eun Lim et al.

Summary: This study found little evidence to support the preventive role of multivitamin use in cancer, except for a slight inverse association with colon cancer. Higher intake of multivitamins was associated with slightly higher risks of overall, prostate, lung, and leukemia cancer in men, and a higher risk of oropharyngeal cancer in women.

JOURNAL OF NUTRITION (2022)

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Article Multidisciplinary Sciences

Cancer risk across mammals

Orsolya Vincze et al.

Summary: The study analyzed data on adult zoo mammals and found that cancer is prevalent and has a high frequency in mammals, with significant differences in cancer mortality rates across different mammalian orders. The research also showed that diet is associated with cancer mortality, with carnivorous mammals facing the highest cancer-related mortality. Furthermore, the study provided unequivocal evidence that cancer mortality risk is largely independent of body mass and adult life expectancy across species.

NATURE (2022)

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Review Biotechnology & Applied Microbiology

Targeting cancer metabolism in the era of precision oncology

Zachary E. Stine et al.

Summary: In the past century, there have been significant advancements in targeting cancer metabolism, but progress in the past decade has been limited. Some metabolism-based drugs for cancer have been successfully developed and are in clinical trials. However, consideration of the metabolism of non-cancer cells is crucial for successful treatment of cancer.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Cell Biology

Modulation of cellular processes by histone and non-histone protein acetylation

Maria Shvedunova et al.

Summary: Lysine acetylation is a crucial protein post-translational modification that plays important roles in cellular and physiological processes. Lysine acetyltransferases and lysine deacetylases regulate gene expression and protein function by controlling acetylation and deacetylation.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Oncology

Soluble and Insoluble Dietary Fiber Consumption and Colorectal Cancer Risk: A Systematic Review and Meta-Analysis

Mehmet Emin Arayici et al.

Summary: The meta-analysis results suggest that there is a similar association between soluble and insoluble dietary fiber intake and the risk of colorectal cancer. The study indicates that dietary fiber plays an important role in reducing CRC risk, especially through the consumption of both soluble and insoluble fiber.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)

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Article Oncology

Fasting- Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Claudio Vernieri et al.

Summary: Cyclic fasting or fasting-mimicking diets (FMD) enhance antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. In a clinical trial, the five-day FMD was found to be safe and resulted in consistent decrease of blood glucose and growth factor concentration, recapitulating metabolic changes observed in preclinical experiments. The FMD also reshapes anticancer immunity and improves clinical outcomes in patients with cancer.

CANCER DISCOVERY (2022)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Article Oncology

A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti-PD-1 Resistance through Effects on the Gut Microbiota

Meriem Messaoudene et al.

Summary: The study demonstrates that oral supplementation with polyphenol-rich berry camu-camu alters gut microbial composition in mice, leading to antitumor activity and enhanced anti-PD-1 response. The active compound castalagin enriches for specific bacteria and induces metabolic changes to support immunotherapy efficacy.

CANCER DISCOVERY (2022)

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Article Oncology

Akkermansia muciniphila administration exacerbated the development of colitis-associated colorectal cancer in mice

Fei Wang et al.

Summary: A. muciniphila may promote the formation of CRC in mice through increasing the early level of inflammation and the proliferation of intestinal epithelial cells.

JOURNAL OF CANCER (2022)

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Article Oncology

Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T Cells

Sara Alavi et al.

Summary: This study explores the role of nicotinamide in preventing and reversing T cell exhaustion, which has important implications for immunotherapy against cancers and viral infections. Nicotinamide supplementation was found to prevent the development of inhibitory receptors in T cells and promote the differentiation of T cells to effector states, suggesting a potential therapeutic strategy for enhancing immune responses.

CANCERS (2022)

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Article Medicine, General & Internal

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial

Sophia Liu et al.

Summary: This randomized clinical trial investigated the effects of urolithin A supplementation on aging-related decline in muscle function. The results showed that urolithin A was safe and well-tolerated, and it improved muscle endurance and plasma biomarkers associated with cellular health. However, it did not significantly improve the 6-minute walk distance and maximal ATP production in hand muscles compared to the placebo. Further research is needed to confirm these findings.

JAMA NETWORK OPEN (2022)

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Article Medicine, Research & Experimental

Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma

Briant Burke et al.

Summary: Skin cancer, particularly basal cell carcinoma, is a common and costly cancer. A study comparing the efficacy of a topical solution containing 30% ascorbic acid with the standard treatment imiquimod showed that ascorbic acid was superior at 8 weeks and non-inferior at 12 weeks in treating low-risk basal cell carcinoma. Ascorbic acid also had fewer side effects compared to imiquimod.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Nutrition & Dietetics

Ketogenic diets consumed during radio-chemotherapy have beneficial effects on quality of life and metabolic health in patients with rectal cancer

Rainer J. Klement et al.

Summary: The study showed that ketogenic diets can improve role, emotional, and social functioning in rectal cancer patients undergoing radio-chemotherapy, while also improving metabolic health markers. Despite being perceived as difficult to implement by approximately 50% of patients, ketogenic diets are feasible as complementary therapies and associated with subjective well-being. The hypothesis that ketogenic diets have beneficial effects on quality of life and metabolic health in rectal cancer patients is supported by the data.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Editorial Material Cell Biology

Modulation of cancer immunotherapy by dietary fibers and over-the-counter probiotics

Laurence Zitvogel et al.

Summary: The human gut microbiota plays a significant role in cancer immunosurveillance. A recent study found that low dietary fiber intake and consumption of commercially available probiotics can both impact the anticancer effects of immunotherapy in mice and patients with advanced melanoma.

CELL METABOLISM (2022)

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Article Gastroenterology & Hepatology

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

Alain P. Gobert et al.

Summary: The study demonstrates that Spd treatment can reduce colitis and carcinogenesis, reversing the effects of SMOX deficiency on colitis and CAC, reducing tumor development, and modulating the microbiome.

GASTROENTEROLOGY (2022)

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Article Biochemistry & Molecular Biology

Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

Nazli Dizman et al.

Summary: Adding a live bacterial product to an immunotherapy combination can enhance the clinical outcome in patients with metastatic renal cell carcinoma, showing longer progression-free survival and higher response rate.

NATURE MEDICINE (2022)

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Article Medicine, General & Internal

Calorie Restriction with or without Time-Restricted Eating in Weight Loss

Deying Liu et al.

Summary: Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Nutrition & Dietetics

Impact of Parenteral Glutamine Supplement on Oncologic Outcomes in Patients with Nasopharyngeal Cancer Treated with Concurrent Chemoradiotherapy

Chih-Chun Wang et al.

Summary: This study aimed to evaluate the impact of parenteral glutamine supplement (dipeptiven) on oncologic outcomes in patients with nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy (CCRT). The results showed that dipeptiven supplementation can reduce treatment-related toxicities and improve treatment efficacy, thereby improving overall survival in NPC patients.

NUTRIENTS (2022)

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Article Oncology

Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer

Safae Terrisse et al.

Summary: Thymus-derived T lymphocytes and the intestinal microbiota play important roles in the efficacy of androgen deprivation therapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Cell Biology

Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance

Yanru Wu et al.

Summary: Dietary fructose, especially in the context of a high-fat western diet, has been linked to type 2 diabetes. This study found that dietary fat enhances fructose metabolism in the small intestine, releasing glycerate into the blood. High systemic levels of glycerate cause damage to pancreatic islet cells and reduce islet sizes, leading to glucose intolerance.

CELL METABOLISM (2022)

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Article Nutrition & Dietetics

Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial

Adeleh Khodabakhshi et al.

Summary: The study evaluated the effects of a ketogenic diet on breast cancer patients undergoing chemotherapy. Results showed a decrease in TNF-alpha and insulin, an increase in IL-10, and reductions in tumor size and staging in the ketogenic diet group.

CLINICAL NUTRITION (2021)

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Article Oncology

Dietary Fiber and Survival in Women with Breast Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies

Ahmad Jayedi et al.

Summary: The study indicates a significant association between increased dietary fiber consumption and reduced risks of all-cause mortality and breast cancer-specific mortality in patients with breast cancer. The quality of evidence is moderate, but further research is needed to confirm the results.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

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Article Oncology

Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy

Lindsey M. Kuehm et al.

Summary: Checkpoint blockade immunotherapy relies on empowering the immune system to fight cancer, with individual factors like diet and obesity potentially impacting patient outcomes. In a mouse model of diet-induced obesity, it was found that dietary fructose played a role in tumor immune evasion, with HO-1 expression identified as a mechanism of resistance and a target for combination cancer immunotherapy.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Nutrition & Dietetics

Metabolic and Signaling Roles of Ketone Bodies in Health and Disease

Patrycja Puchalska et al.

Annual Review of Nutrition (2021)

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Review Oncology

Effects of Circulating 25(OH)D Status in Advanced Colorectal Cancer Patients Undergoing Chemotherapy: A Systematic Review

Xiaofeng Zeng et al.

Summary: Higher circulating 25(OH)D level is associated with better disease outcomes in advanced CRC patients undergoing chemotherapy, contributing to improved prognosis.

ANTICANCER RESEARCH (2021)

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Review Oncology

Immunomodulation by targeted anticancer agents

Giulia Petroni et al.

Summary: Targeted anticancer agents are designed to inhibit specific molecular alterations that support oncogenesis or tumor progression, but they may also have immunomodulatory effects that can influence therapeutic efficacy. Harnessing these effects could potentially lead to superior clinical outcomes.

CANCER CELL (2021)

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Review Biochemistry & Molecular Biology

Hallmarks of Health

Carlos Lopez-Otin et al.

Summary: Health is more than just the absence of disease; it involves a combination of organizational and dynamic features that maintain physiology. Biological causes of health include spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress. Disruption of these features can lead to pathogenic processes.

CELL (2021)

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Article Cell Biology

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells

Sangmoo Jeong et al.

Summary: Leukemic cells exhibit a significant dependence on the de novo serine synthesis pathway (SSP) in fructose-rich conditions, and inhibition of SSP can reduce leukemia engraftment in mice in the presence of high fructose, highlighting the essential role of SSP in the metabolic plasticity of leukemic cells.

CELL METABOLISM (2021)

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Article Nutrition & Dietetics

A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial

Cristian Del Bo et al.

Summary: This study demonstrates that a polyphenol-rich diet can reduce serum zonulin levels, decrease blood pressure, and increase beneficial bacteria in the gut. These findings may open avenues for further research on dietary interventions for managing intestinal permeability, inflammation, and gut function in diverse populations.

CLINICAL NUTRITION (2021)

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Review Cell Biology

Sweet death: Fructose as a metabolic toxin that targets the gut-liver axis

Mark A. Febbraio et al.

Summary: Fructose is closely related to metabolic diseases, with consumption of high-fructose corn syrup correlating with increased rates of obesity and diabetes. In addition to being metabolized in the liver, fructose has been found to be metabolized in the small intestine, leading to deterioration of the intestinal epithelial barrier. The gut-liver axis plays a key role in fructose metabolism and pathology, along with the direct effects of fructose on liver metabolism.

CELL METABOLISM (2021)

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Review Cell Biology

Molecular aspects of fructose metabolism and metabolic disease

Mark A. Herman et al.

Summary: Excessive sugar consumption, especially in the form of fructose, is increasingly recognized as a contributing factor to obesity and cardiometabolic disease. While fructose can serve as a physiological signal of normal dietary sugar consumption, overconsumption of fructose may contribute to the pathogenesis of metabolic disease. New therapeutic options for treating metabolic disease are being considered based on a better understanding of fructose metabolism.

CELL METABOLISM (2021)

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Review Cardiac & Cardiovascular Systems

NAD+ Metabolism in Cardiac Health, Aging, and Disease

Mahmoud Abdellatif et al.

Summary: NAD(+) plays a crucial role in metabolic health and age-related diseases, with supplementation showing positive effects. Decline in NAD(+) pools is associated with cardiovascular disease risk factors, and replenishment can improve related conditions.

CIRCULATION (2021)

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Review Oncology

Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?

Jiajie Hou et al.

Summary: The immune system plays crucial roles in cancer development and treatment, with adaptive immunity capable of preventing or constraining cancer and innate immunity and inflammation often promoting tumorigenesis. While immunotherapies derived from preclinical studies have shown efficacy in treating cancer, treatments targeting cancer-associated inflammation still require successful implementation. Anti-inflammatory agents have the potential to delay cancer onset and enhance the efficacy of conventional and next-generation cancer therapies.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Cell Biology

NAD+ metabolism and its roles in cellular processes during ageing

Anthony J. Covarrubias et al.

Summary: NAD(+) is a crucial coenzyme in redox reactions and plays a pivotal role in energy metabolism. Its levels decline with age, and raising NAD(+) levels is being explored as a potential strategy to extend human lifespan and healthspan. NAD(+) influences key cellular processes and functions, including metabolic pathways, DNA repair, and cellular senescence, with implications for healthy aging and age-related diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

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Article Medicine, Research & Experimental

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere et al.

Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.

JCI INSIGHT (2021)

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Article Oncology

The Bidirectional Relationship Between Cancer Epigenetics and Metabolism

Luke T. Izzo et al.

Summary: This article discusses the bidirectional relationship between epigenetics and metabolism in cancer, including epigenetic control of metabolism and metabolic regulation of chromatin-modifying enzymes. This cross talk plays a crucial role in tumor growth and proliferation, with potential for improving cancer therapy.

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 5, 2021 (2021)

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Article Nutrition & Dietetics

The Role of Vitamin D Intake on the Prognosis and Incidence of Lung Cancer: A Systematic Review and Meta-Analysis

Mingxia QIAN et al.

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2021)

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Article Cell Biology

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Claudia Grajeda-Iglesias et al.

Aging-US (2021)

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Article Medicine, General & Internal

Once-Weekly Semaglutide in Adults with Overweight or Obesity

John P. H. Wilding et al.

Summary: The study demonstrates that for individuals with obesity, once-weekly use of 2.4 mg semaglutide in combination with lifestyle intervention can lead to sustained and clinically relevant weight loss, with significant improvements in cardiometabolic risk factors and physical functioning reported by participants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Christine N. Spencer et al.

Summary: The study suggests that dietary fiber intake is associated with significantly improved progression-free survival in melanoma patients receiving ICB treatment, especially without the use of probiotics. Preclinical studies demonstrate that a low-fiber diet or probiotics can impair the treatment response to anti-PD-1 therapy, leading to a lower frequency of interferon-gamma-positive cytotoxic T cells in the tumor microenvironment.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

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Review Oncology

From Liver Fat to Cancer: Perils of the Western Diet

Ju Youn Kim et al.

Summary: NASH and HCC, two liver diseases related to obesity, are influenced by cholesterol and metabolic regulators in their development.

CANCERS (2021)

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Review Nutrition & Dietetics

Ketogenic Diet for Cancer: Critical Assessment and Research Recommendations

Jordin Lane et al.

Summary: Despite preclinical studies suggesting potential benefits of the ketogenic diet in cancer, human clinical trials have yielded mixed results, leaving the actual impact of the diet on cancer development uncertain and necessitating further research.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress

Munehiro Kitada et al.

Summary: Methionine restriction (MetR) impacts lifespan extension and metabolic health by reducing oxidative stress through various mechanisms, such as activating autophagy, increasing hydrogen sulfide and polyamine production, and inhibiting mitochondrial reactive oxygen species generation.

BIOMEDICINES (2021)

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Review Environmental Sciences

Dietary Fiber Intake and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis of Observational Studies

Daniele Nucci et al.

Summary: Dietary fiber intake reduces the risk of pancreatic cancer, especially among women, and the strength of the association increases when case-control studies are conducted. Policymakers and clinicians should promote interventions to increase awareness of high-fiber diets in the population, both in practice and in public health policy.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Oncology

Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase

Qinghong Han et al.

Summary: Methionine addiction is a fundamental characteristic of cancer, and restricting methionine shows promise for cancer therapy. Clinical studies have demonstrated that oral recombinant methioninase (o-rMETase) can effectively reduce PSA levels in patients with prostate cancer.

ANTICANCER RESEARCH (2021)

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Article Oncology

Dietary Fructose Promotes Prostate Cancer Growth

Daniela Carreno et al.

Summary: Prostate cancer cells overexpress fructose transporters compared with benign cells, and fructose can stimulate proliferation and invasion of prostate cancer cells. This study suggests that fructose may serve as an alternative energy source for prostate cancer cells, promoting their growth and aggressiveness both in vitro and in vivo.

CANCER RESEARCH (2021)

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Review Immunology

Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?

Leonce Kouakanou et al.

Summary: Vitamin C at high doses has direct anti-cancer activity through oxidant and epigenetic mechanisms, killing tumor cells. Recent studies also suggest that pharmacologic-dose Vitamin C can control tumor growth by modulating the immune system.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Infectious Diseases

Use of antibiotics is associated with worse clinical outcomes in patients with cancer treated with immune checkpoint inhibitors: A systematic review and meta-analysis

Maria Tsikala-Vafea et al.

Summary: In cancer patients treated with ICIs, recent use of antibiotics is associated with worse clinical outcomes, including shorter overall survival, decreased response rate, and more disease progression. This negative association is stronger in patients with renal cell carcinoma or melanoma.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Biochemistry & Molecular Biology

The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review

Marcelo Villagran et al.

Summary: Vitamin C plays a significant role in cancer prevention and treatment, with studies showing its potential benefits in preventing pulmonary and breast cancer, as well as its synergistic effects with pancreatic cancer drugs. However, a Mendelian randomized study did not find an association between vitamin C and cancer prevention. Ongoing research is needed to further explore the therapeutic role of vitamin C in cancer through new phase II and III clinical trials.

ANTIOXIDANTS (2021)

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Article Medicine, General & Internal

Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial

Lone B. Enebo et al.

Summary: The study aimed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the combination of Cagrilintide and Semaglutide for weight management. Results showed that concomitant treatment with Cagrilintide and Semaglutide was well tolerated with an acceptable safety profile. Larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination.

LANCET (2021)

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Article Biochemistry & Molecular Biology

Energy status dictates PD-L1 protein abundance and anti-tumor to enable blockade

Xiaoming Dai et al.

Summary: The ketogenic diet-induced changes in energy status were found to enhance the efficacy of anti-CTLA-4 immunotherapy through various mechanisms, such as decreasing PD-L1 protein levels and increasing expression of IFNs and antigen presentation genes. AMPK activation plays a crucial role in these mechanisms, highlighting its importance in regulating the immune response to immune checkpoint blockade.

MOLECULAR CELL (2021)

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Article Multidisciplinary Sciences

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

William S. Harris et al.

Summary: The study found that higher levels of omega-3 fatty acids in the blood are associated with a lower risk of all-cause mortality, particularly with long chain omega-3 fatty acids. This association may help reduce the risk of death from cardiovascular disease, cancer, and other causes.

NATURE COMMUNICATIONS (2021)

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Review Oncology

The Next Decade of Immune Checkpoint Therapy

Padmanee Sharma et al.

Summary: Immune checkpoint therapy can provide durable antitumor responses for subsets of cancer patients, but challenges remain in understanding resistance mechanisms, optimizing patient selection, managing immune-related adverse events, and identifying rational therapeutic combinations. A focused approach encompassing clinical and basic research with integration of reverse translational studies is needed to address these challenges and guide the development of novel combination strategies.

CANCER DISCOVERY (2021)

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Review Medicine, General & Internal

Association of Obesity With Survival Outcomes in Patients With Cancer A Systematic Review and Meta-analysis

Fausto Petrelli et al.

Summary: Obesity is associated with increased mortality in cancer patients overall, but patients with obesity and certain types of cancer such as lung cancer, renal cell carcinoma, and melanoma may have better survival outcomes compared to non-obese patients with the same cancers. Weight-reducing strategies could potentially help reduce mortality in these patients.

JAMA NETWORK OPEN (2021)

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Article Nutrition & Dietetics

Is Food Addictive? A Review of the Science

Ashley N. Gearhardt et al.

Annual Review of Nutrition (2021)

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Article Medicine, General & Internal

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study

Yuanqing Fu et al.

Summary: The study found no evidence supporting a causal relationship between circulating vitamin C concentration and the risk of the five most common cancers in European populations, although small effect sizes cannot be ruled out.

BMC MEDICINE (2021)

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Article Oncology

Diabetes Risk Reduction Diet and Survival after Breast Cancer Diagnosis

Tengteng Wang et al.

Summary: This study suggests that greater adherence to a diabetes risk reduction diet after diagnosis is associated with improved survival outcomes among a large number of breast cancer survivors, indicating that postdiagnosis dietary modifications consistent with type II diabetes prevention may be crucial for breast cancer survivors.

CANCER RESEARCH (2021)

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Article Oncology

Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP-Mediated Mitochondrial Dysfunction

Rong Jin et al.

Summary: The study found that dietary oils high in linoleic acid (LA) can promote mammary tumor growth by impairing anti-tumor T-cell responses. Inhibiting E-FABP activity may represent a novel strategy to enhance T-cell function in the prevention and treatment of obesity-associated cancers.

CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Gut-microbiota-targeted diets modulate human immune status

Hannah C. Wastyk et al.

Summary: This study investigated the effects of plant-based fiber and fermented foods on the human microbiome and immune system, finding that a high-fiber diet increased glycan-degrading carbohydrate active enzymes while a high-fermented-food diet increased microbiome diversity and decreased inflammatory markers. The data suggest that coupling dietary interventions with immune and microbiome profiling can provide personalized and populationwide insights, with fermented foods potentially valuable in countering decreased microbiome diversity and increased inflammation in industrialized societies.

CELL (2021)

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Article Nutrition & Dietetics

A ketogenic diet consumed during radiotherapy improves several aspects of quality of life and metabolic health in women with breast cancer

Rainer J. Klement et al.

Summary: The study showed that ketogenic diets (KDs) have potential benefits for women with early-stage breast cancer undergoing radiotherapy, including significant improvements in emotional functioning, social functioning, sleep quality, future perspectives and systemic therapy side effects. The KD group also showed improvements in metabolic health biomarkers compared to the standard diet (SD) group, indicating a safe and beneficial impact of KD during radiotherapy for breast cancer patients.

CLINICAL NUTRITION (2021)

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Article Nutrition & Dietetics

Impact of a ketogenic diet intervention during radiotherapy on body composition: IV. Final results of the KETOCOMP study for rectal cancer patients

Rainer J. Klement et al.

Summary: In rectal cancer patients undergoing curative radiotherapy, a ketogenic diet (KD) significantly reduced body weight and fat mass while preserving skeletal muscle mass. There was a trend for KDs contributing synergistically to pathological tumor response, indicating potential benefits in larger studies.

CLINICAL NUTRITION (2021)

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Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer

Aline Yammine et al.

Summary: The Mediterranean diet, rich in polyphenols, plays a crucial role in preventing various diseases, especially colorectal cancer. Selected dietary phytophenols can benefit health by increasing polyphenol metabolites and influencing the microbiome. The emergence of polyphenol formulations may enhance the effectiveness of the Mediterranean diet in cancer prevention.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Dietary fructose improves intestinal cell survival and nutrient absorption

Samuel R. Taylor et al.

Summary: Fructose consumption is linked to the increasing rates of obesity and cancer globally. Dietary fructose metabolism occurs in the small intestine, where it is transported and phosphorylated to form fructose 1-phosphate, which accumulates in the cell. The ability of fructose to promote cell survival and increase intestinal villus length expands the surface area of the gut and enhances nutrient absorption and adiposity.

NATURE (2021)

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Article Medicine, General & Internal

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

Juan P. Frias et al.

Summary: The study showed that Tirzepatide was both noninferior and superior to Semaglutide in terms of the mean change in glycated hemoglobin levels for patients with type 2 diabetes over 40 weeks. Additionally, reductions in body weight were greater with Tirzepatide compared to Semaglutide, with similar rates of gastrointestinal adverse events reported in both groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Multidisciplinary Sciences

An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites

Nikos Papadimitriou et al.

Summary: Research suggests that diet and nutrition play a role in the risk of developing various types of cancer, with certain food/nutrient associations showing strong evidence. Alcohol consumption, dairy intake, and calcium are associated with different risks of developing cancer. Studies using umbrella reviews of meta-analyses can provide insights into the strength of evidence linking food and nutrients to cancer risk.

NATURE COMMUNICATIONS (2021)

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Review Oncology

Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?

Lisa Derosa et al.

Summary: The dialogue between cancer and the immune system is greatly impacted by microenvironmental factors, especially the mucosal microbiota in the intestinal ecosystem. Antibiotics can reduce the effectiveness of immune checkpoint inhibitors, while fecal microbial transplantation may restore responsiveness in resistant melanoma patients. Understanding the role of gut bacteria in anticancer therapies is essential for future microbiota-centered interventions in immuno-oncology.

CANCER DISCOVERY (2021)

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Review Nutrition & Dietetics

Vitamin B6 in Health and Disease

Kamilla Stach et al.

Summary: Vitamin B6 is a crucial coenzyme involved in over 150 biochemical reactions in the human body, playing a role in metabolism and cellular signaling. It acts as an antioxidant and is capable of reducing advanced glycation end products. Deficiency in Vitamin B6 may be associated with diseases such as diabetes, heart disease, cancer, and the prognosis of COVID-19.

NUTRIENTS (2021)

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Article Cell Biology

NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

Yuetong Wang et al.

Summary: Research reveals that dysfunctional T cells in the tumor microenvironment are associated with decreased levels of NAMPT and NAD(+), and supplementation with NAD(+) can enhance the killing efficacy of T cells.

CELL REPORTS (2021)

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Review Endocrinology & Metabolism

The Effects of Diet and Exercise on Endogenous Estrogens and Subsequent Breast Cancer Risk in Postmenopausal Women

Alleigh G. Wiggs et al.

Summary: Endogenous estrogens are associated with breast cancer risk, particularly in postmenopausal women. Nutritional and exercise interventions have been shown to modify estrogen levels and metabolism, potentially reducing the risk of breast cancer. Studies combining diet and exercise interventions demonstrate better control of estrogen forms and levels, suggesting they may be the most effective strategies for preventing breast cancer in postmenopausal women.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Oncology

IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms-

Qi Wu et al.

Summary: The study identified PPP as a potent autophagy inducer by inhibiting the tyrosine kinase activity of IGF1R. In animal models, PPP improved the therapeutic efficacy of chemoimmunotherapy, but this effect was lost when tumors were insensitive to PPP or autophagy-incompetent.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Oncology

Metabolic features of cancer cells impact immunosurveillance

Adrien Joseph et al.

Summary: Tumors adapt their metabolism to resist therapeutic interventions like cisplatin, affecting the local immunosurveillance. This study found that PDXK and PAR levels impact the response to cisplatin, providing new insights into therapeutic failures in cancer treatment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Intermittent and Periodic Fasting, Hormones, and Cancer Prevention

Giulia Salvadori et al.

Summary: Hormonal and growth factor alterations can affect cellular processes, leading to cell mutations and malignant transformation, while nutrient restriction has been shown to delay age-related diseases and extend lifespan.

CANCERS (2021)

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Article Food Science & Technology

Evaluation of the Effects of Different Dietary Patterns on Breast Cancer: Monitoring Circulating Tumor Cells

Xiuxiu Wang et al.

Summary: The study found that high-salt, high-sugar, and high-fat diets significantly promoted the increase in CTC numbers, while ketogenic, low-fat, low-protein, diet restriction, and Mediterranean diets delayed the increase. Through in-depth study of the effects of different dietary patterns on tumor growth and metastasis, a new horizon in future cancer treatments may be expanded.

FOODS (2021)

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Article Oncology

A Randomized Trial of Calcium Plus Vitamin D Supplementation and Risk of Ductal Carcinoma In Situ of the Breast

Rita Peila et al.

Summary: The study found that calcium plus vitamin D (CaD) supplementation was associated with a reduced risk of ductal carcinoma in situ (DCIS) in postmenopausal women. The intervention group had a lower risk of DCIS throughout the follow-up period and during the postintervention phase. Those who used CaD personal supplements in combination with the trial intervention had a lower risk of DCIS compared to the trial placebo group that did not use personal supplementation.

JNCI CANCER SPECTRUM (2021)

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Review Oncology

Cancer metabolism: looking forward

Inmaculada Martinez-Reyes et al.

Summary: This Perspective discusses the main themes in cancer metabolism research, focusing on the relationship between tumour initiation and progression with metabolic reprogramming, as well as the importance of tumor microenvironment and metabolic regulation.

NATURE REVIEWS CANCER (2021)

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Article Immunology

Changes in Transcript, Metabolite, and Antibody Reactivity During the Early Protective Immune Response in Humans to Mycobacterium tuberculosis Infection

January Weiner et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Oncology

Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study

Adeleh Khodabakhshi et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2020)

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Article Clinical Neurology

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Khalil S. Rawji et al.

ACTA NEUROPATHOLOGICA (2020)

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Article Nutrition & Dietetics

One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study

Rama Kiblawi et al.

BRITISH JOURNAL OF NUTRITION (2020)

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Article Oncology

Vitamin B6 Addiction in Acute Myeloid Leukemia

Chi-Chao Chen et al.

CANCER CELL (2020)

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Article Nutrition & Dietetics

Intermittent fasting 5:2 diet: What is the macronutrient and micronutrient intake and composition?

E. L. Scholtens et al.

CLINICAL NUTRITION (2020)

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Article Oncology

Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 x 2, Phase II Trial

Michael Luebbert et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

Dietary Modification and Breast Cancer Mortality: Long-Term Follow-Up of the Women's Health Initiative Randomized Trial

Rowan T. Chlebowski et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221)

Christine B. Ambrosone et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Multidisciplinary Sciences

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

Rebecca A. Luchtel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

High-dose vitamin C enhances cancer immunotherapy

Alessandro Magri et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Oncology

Dietary Approaches to Cancer Therapy

Mylene Tajan et al.

CANCER CELL (2020)

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Article Rheumatology

Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis

Gabsik Yang et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Review Pharmacology & Pharmacy

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Amit S. Choudhari et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Oncology

One-carbon metabolism-related micronutrients intake and risk for hepatocellular carcinoma: A prospective cohort study

Samuel O. Antwi et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Cell Biology

Control of brain tumor growth by reactivating myeloid cells with niacin

Susobhan Sarkar et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Oncology

Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance

Tatiana Shaurova et al.

CANCERS (2020)

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Review Multidisciplinary Sciences

Dietary modifications for enhanced cancer therapy

Naama Kanarek et al.

NATURE (2020)

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Article Nutrition & Dietetics

Grain and dietary fiber intake and bladder cancer risk: a pooled analysis of prospective cohort studies

Evan Y. W. Yu et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

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Review Biochemistry & Molecular Biology

The Role of Diet in Cancer Prevention and Chemotherapy Efficacy

Steven D. Mittelman

ANNUAL REVIEW OF NUTRITION, VOL 40, 2020 (2020)

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Review Biochemistry & Molecular Biology

Nutritional Aspects of Spermidine

Frank Madeo et al.

ANNUAL REVIEW OF NUTRITION, VOL 40, 2020 (2020)

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Article Oncology

Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor-induced colitis

Shilpa Grover et al.

CANCER (2020)

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Article Medicine, General & Internal

Association Between Plant and Animal Protein Intake and Overall and Cause-Specific Mortality

Jiaqi Huang et al.

JAMA INTERNAL MEDICINE (2020)

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Review Multidisciplinary Sciences

Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation

Prashant Regmi et al.

ISCIENCE (2020)

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Article Multidisciplinary Sciences

Fasting-mimicking diet and hormone therapy induce breast cancer regression

Irene Caffa et al.

NATURE (2020)

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Review Oncology

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Lorenzo Galluzzi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Fasting mimicking diet as an adjunct toneoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

Stefanie de Groot et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Mari B. Ishak Gabra et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Aitziber Buque et al.

NATURE COMMUNICATIONS (2020)

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Review Nutrition & Dietetics

Postbiotics-A Step Beyond Pre- and Probiotics

Jakub Zolkiewicz et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Yingjie Bian et al.

NATURE (2020)

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Review Medicine, Research & Experimental

Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview

Li Changxing et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel et al.

CELL (2020)

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Article Nutrition & Dietetics

Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study

Chu-Yi Huang et al.

NUTRIENTS (2020)

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Article Oncology

Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade

Daniel Ajona et al.

NATURE CANCER (2020)

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Article Oncology

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

Thai Q. Tran et al.

NATURE CANCER (2020)

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Article Oncology

Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice

Benson Chellakkan Selvanesan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Multidisciplinary Sciences

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Aurelie Fluckiger et al.

SCIENCE (2020)

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Review Oncology

Dietary patterns and cancer risk

Susan E. Steck et al.

NATURE REVIEWS CANCER (2020)

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Article Endocrinology & Metabolism

Fructose stimulated de novo lipogenesis is promoted by inflammation

Jelena Todoric et al.

NATURE METABOLISM (2020)

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Article Oncology

Vitamin B6 catabolism and lung cancer risk: results from the Lung Cancer Cohort Consortium (LC3)

H. Zuo et al.

ANNALS OF ONCOLOGY (2019)

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Review Oncology

Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials

N. Keum et al.

ANNALS OF ONCOLOGY (2019)

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Review Cell Biology

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Frank Madeo et al.

CELL METABOLISM (2019)

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Article Nutrition & Dietetics

The effects of two vitamin D regimens on ulcerative colitis activity index, quality of life and oxidant/anti-oxidant status

Sara Karimi et al.

NUTRITION JOURNAL (2019)

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Article Multidisciplinary Sciences

High-fructose corn syrup enhances intestinal tumor growth in mice

Marcus D. Goncalves et al.

SCIENCE (2019)

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Article Oncology

Association of Intake of Whole Grains and Dietary Fiber With Risk of Hepatocellular Carcinoma in US Adults

Wanshui Yang et al.

JAMA ONCOLOGY (2019)

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Article Gastroenterology & Hepatology

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised crossover trial

Edward S. Chambers et al.

GUT (2019)

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Article Multidisciplinary Sciences

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Xia Gao et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

Clara Depommier et al.

NATURE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Clea Barcena et al.

NATURE MEDICINE (2019)

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Article Cell Biology

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Slaven Stekovic et al.

CELL METABOLISM (2019)

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Article Multidisciplinary Sciences

α-Ketoglutarate links p53 to cell fate during tumour suppression

John P. Morris et al.

NATURE (2019)

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Article Oncology

A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice

Sarah Levesque et al.

ONCOIMMUNOLOGY (2019)

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Editorial Material Cell Biology

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

Frank Madeo et al.

AUTOPHAGY (2019)

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Article Nutrition & Dietetics

Effects of prebiotics on immunologic indicators and intestinal microbiota structure in perioperative colorectal cancer patients

Xiaoliang Xie et al.

NUTRITION (2019)

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Review Oncology

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sydney M. Sanderson et al.

NATURE REVIEWS CANCER (2019)

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Review Oncology

Acute Promyelocytic Leukemia: A History over 60 Years-From the Most Malignant to the most Curable Form of Acute Leukemia

Xavier Thomas

ONCOLOGY AND THERAPY (2019)

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Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

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Article Biochemistry & Molecular Biology

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

Christine A. Olson et al.

CELL (2018)

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Article Cell Biology

Low-Protein Diet Induces IRE1 alpha-Dependent Anticancer Immunosurveillance

Camila Rubio-Patino et al.

CELL METABOLISM (2018)

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Article Oncology

Impaired functional vitamin B6 status is associated with increased risk of lung cancer

Despoina Theofylaktopoulou et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

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Article Nutrition & Dietetics

A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer

Caroline W. Cohen et al.

JOURNAL OF NUTRITION (2018)

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Article Oncology

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis

Jennifer L. McQuade et al.

LANCET ONCOLOGY (2018)

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Review Multidisciplinary Sciences

The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

Laurence Zitvogel et al.

SCIENCE (2018)

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Article Cell Biology

TORC1 inhibition enhances immune function and reduces infections in the elderly

Joan B. Mannick et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Oncology

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

Niraj Shenoy et al.

CANCER CELL (2018)

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Article Oncology

Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer

Matthew S. Alexander et al.

CANCER RESEARCH (2018)

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Article Multidisciplinary Sciences

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Benjamin D. Hopkins et al.

NATURE (2018)

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Article Cell Biology

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

Clea Barcena et al.

CELL REPORTS (2018)

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Review Biochemistry & Molecular Biology

Carbotoxicity-Noxious Effects of Carbohydrates

Guido Kroemer et al.

CELL (2018)

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Article Nutrition & Dietetics

Dietary fiber intake and reduced risk of ovarian cancer: a meta-analysis

Bowen Zheng et al.

NUTRITION JOURNAL (2018)

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Article Oncology

Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk

Hui Zuo et al.

CANCER RESEARCH (2018)

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Article Oncology

Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy

Ashley Orillion et al.

CLINICAL CANCER RESEARCH (2018)

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Review Food Science & Technology

Vegetarian, vegan diets and multiple health outcomes: A systematic review with meta-analysis of observational studies

Monica Dinu et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

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Review Oncology

Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis

Simone Mocellin et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Biochemistry & Molecular Biology

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Hubert Plovier et al.

NATURE MEDICINE (2017)

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Review Oncology

Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis

Simone Mocellin et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Multidisciplinary Sciences

Caloric restriction improves health and survival of rhesus monkeys

Julie A. Mattison et al.

NATURE COMMUNICATIONS (2017)

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Article Gastroenterology & Hepatology

Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

Maria Carlota Dao et al.

GUT (2016)

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Article Oncology

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Federico Pietrocola et al.

CANCER CELL (2016)

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Article Oncology

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

Stefano Di Biase et al.

CANCER CELL (2016)

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Article Oncology

Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential

Wen-Lian Chen et al.

CANCER CELL (2016)

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Review Cell Biology

Obesity and Cancer: The Oil that Feeds the Flame

Joan Font-Burgada et al.

CELL METABOLISM (2016)

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Review Cell Biology

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

Valter D. Longo et al.

CELL METABOLISM (2016)

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Article Cell Biology

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress

De Huang et al.

CELL RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Urolithin A induces mitophagy and prolongs lifespan in C-elegans and increases muscle function in rodents

Dongryeol Ryu et al.

NATURE MEDICINE (2016)

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Article Oncology

The ratio of CD8(+)/FOXP3 T lymphocytes infiltrating breast tissues predicts the relapse of ductal carcinoma in situ

Michaela Semeraro et al.

ONCOIMMUNOLOGY (2016)

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Article Oncology

Prolonged Nightly Fasting and Breast Cancer Prognosis

Catherine R. Marinac et al.

JAMA ONCOLOGY (2016)

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Article Nutrition & Dietetics

Dietary polyamine intake and colorectal cancer risk in postmenopausal women

Ashley J. Vargas et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2015)

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Article Biochemistry & Molecular Biology

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

Christopher Hine et al.

CELL (2015)

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Article Cell Biology

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

Sebastian Brandhorst et al.

CELL METABOLISM (2015)

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Review Biochemistry & Molecular Biology

Autophagy in malignant transformation and cancer progression

Lorenzo Galluzzi et al.

EMBO JOURNAL (2015)

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Review Oncology

Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis

Mary C. Playdon et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Article Biochemistry & Molecular Biology

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Yun-Hee Youm et al.

NATURE MEDICINE (2015)

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Review Biochemistry & Molecular Biology

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