In silico and in vivo study of adulticidal activity from Ayapana triplinervis essential oils nano- emulsion against Aedes aegypti

Nanoinsecticides of plant origin have advantages in the resistance of Aedes aegypti, vectors of infectious diseases. The objective of this study was to evaluate the insecticidal potential of Ayapana triplinervis essential oil nano-emulsions using in silico and in vivo assays in an Aedes aegypti model. Molecular docking showed that minority compounds present in the morphotype A essential oil have a more significant binding affinity to inhibit acetylcholinesterase and juvenile hormone receptors. Aedes aegypti adults were susceptible to A. triplinervis at 150 mg.mL-1 in a diagnostic time of 15 min for morphotype A essential oil nano-emulsion and 45 min for morphotype B essential oil nano-emulsion. The evaluation of toxicity in Swiss albino mice indicated that the nano-emulsions had low acute dermal toxicity and presented LD50 greater than 2000 mg.

Automated summary

This study evaluated the insecticidal potential of Ayapana triplinervis essential oil nano-emulsions and found that they have a high lethality against Aedes aegypti adults. Additionally, the nano-emulsions showed low acute dermal toxicity in mice.