期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-34040-y
关键词
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资金
- National Natural Science Foundation of China [32170229]
- National Key Research and Development Program of China [2021YFF1000900]
- United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/J/000PR9788, BB/L025000/1, BB/N022572/1]
- European Research Council [ERC: 680324]
- Human Frontier Science Program Fellowship [LT001077/2021-L]
- Shenzhen Basic Research Project [JCYJ20180507181642811]
- Research Grants Council of the Hong Kong SAR, China Projects [CityU 11100421, CityU 11101519, CityU 11100218, N_CityU110/17]
- Croucher Foundation Project [9509003]
- State Key Laboratory of Marine Pollution Director Discretionary Fund
- Norwich Research Park Science links seed fund
- Norwich Bioscience Institutes Partnership's Computing infrastructure for Science (CiS) group through the provision of a High-Performance Computing Cluster
- John Innes Centre Informatics team
This study analyzes the nucleotide composition of plant transcriptomes and their corresponding habitats, revealing that plants in cold climates have guanine-enriched transcriptomes that are prone to forming RNA G-quadruplex structures. The formation of RNA G-quadruplexes in response to cold enhances mRNA stability and promotes plant cold response.
Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown. Here, we systematically analyze the nucleotide composition of transcriptomes across 1000 plants (1KP) and their corresponding habitats. Intriguingly, we find that plants growing in cold climates have guanine (G)-enriched transcriptomes, which are prone to forming RNA G-quadruplex structures. Both immunofluorescence detection and in vivo structure profiling reveal that RNA G-quadruplex formation in plants is globally enhanced in response to cold. Cold-responsive RNA G-quadruplexes strongly enhanced mRNA stability, rather than affecting translation. Disruption of individual RNA G-quadruplex promotes mRNA decay in the cold, leading to impaired plant cold response. Therefore, we propose that plants adopted RNA G-quadruplex structure as a molecular signature to facilitate their adaptation to the cold during evolution. During evolution, plants have adapted to habitats with distinct temperature ranges. In this study, scientists report that a specific RNA structure motif, RNA G-quadruplex (RG4) is enriched across genomes of plant species growing in colder climates.
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