期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-32558-9
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资金
- Deutsche Forschungsgemeinschaft [CRC1158]
- Union Hospital, Tongji Medical college, Huazhong University of Science and Technology
- China Scholarship Council
- Studienstiftung des Deutschen Volkes (German National Merit Program)
- Ministry of Science, Research and the Arts Baden-Wurttemberg (MWK)
- German Research Foundation (DFG) [INST 35/1314-1 FUGG, INST 35/1503-1 FUGG]
This study reveals the crucial role of the basal nucleus of Meynert (NBM) in the perception and processing of pain. The NBM modulates neocortical activity to affect pain sensitivity and is enhanced during inflammatory pain behavior. Understanding the involvement of NBM in pain mechanisms may lead to new therapeutic targets for pain management.
The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer's and Parkinson's dementias. Despite the crucial role of neocortical domains in pain perception, however, the NBM has not been studied in models of chronic pain. Here, using in vivo tetrode recordings in behaving mice, we report that beta and gamma oscillatory activity is evoked in the NBM by noxious stimuli and is facilitated at peak inflammatory pain-like behavior. Optogenetic and chemogenetic cell-specific, reversible manipulations of NBM cholinergic-GABAergic neurons reveal their role in endogenous control of nociceptive hypersensitivity, which are manifest via projections to the prelimbic cortex, resulting in layer 5-mediated antinociception. Our data unravel the importance of the NBM in top-down control of neocortical processing of pain-like behavior.
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