相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Compstatins: the dawn of clinical C3-targeted complement inhibition
Christina Lamers et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2022)
From discovery to approval: A brief history of the compstatin family of complement C3 inhibitors
Dimitrios C. Mastellos et al.
CLINICAL IMMUNOLOGY (2022)
Complement C3 inhibition in severe COVID-19 using compstatin AMY-101
Panagiotis Skendros et al.
SCIENCE ADVANCES (2022)
Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity
Marco Mannes et al.
BLOOD (2021)
Tipping the balance: intricate roles of the complement system in disease and therapy
Richard B. Pouw et al.
SEMINARS IN IMMUNOPATHOLOGY (2021)
Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria
Peter Hillmen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation
Hatice Hasturk et al.
JOURNAL OF CLINICAL INVESTIGATION (2021)
Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells
Inge Baas et al.
HAEMATOLOGICA (2020)
Computational analysis of complement inhibitor compstatin using molecular dynamics
Didier Devaurs et al.
JOURNAL OF MOLECULAR MODELING (2020)
C3inhibition with pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria treated with eculizumab
Carlos de Castro et al.
AMERICAN JOURNAL OF HEMATOLOGY (2020)
Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy
Dimitrios C. Mastellos et al.
CLINICAL IMMUNOLOGY (2020)
Clinical promise of next-generation complement therapeutics
Dimitrios C. Mastellos et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Complement Nomenclature - Deconvoluted
Suzanne S. Bohlson et al.
FRONTIERS IN IMMUNOLOGY (2019)
New Analogs of the Complement C3 Inhibitor Compstatin with Increased Solubility and Improved Pharmacokinetic Profile
Nadja Berger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
SWISS-MODEL: homology modelling of protein structures and complexes
Andrew Waterhouse et al.
NUCLEIC ACIDS RESEARCH (2018)
Novel Immunoassay for Complement Activation by PF4/Heparin Complexes
Sanjay Khandelwal et al.
THROMBOSIS AND HAEMOSTASIS (2018)
Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood
Jan-Michael Abicht et al.
XENOTRANSPLANTATION (2017)
Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses
Xiaoguang Xue et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses
Xiaoguang Xue et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40
Junxiang Wang et al.
CLINICAL IMMUNOLOGY (2016)
Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode
Federico Forneris et al.
EMBO JOURNAL (2016)
Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity
Georgia Sfyroera et al.
JOURNAL OF IMMUNOLOGY (2015)
Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria
Antonio M. Risitano et al.
BLOOD (2014)
Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape
Dimitrios C. Mastellos et al.
EXPERT REVIEW OF HEMATOLOGY (2014)
How good are my data and what is the resolution?
Philip R. Evans et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties
Hongchang Qu et al.
IMMUNOBIOLOGY (2013)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties
Christoph Q. Schmidt et al.
JOURNAL OF IMMUNOLOGY (2013)
Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg
Goran Bajic et al.
PROTEIN SCIENCE (2013)
Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency
Hongchang Qu et al.
MOLECULAR IMMUNOLOGY (2011)
XDS
Wolfgang Kabsch
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation
Federico Forneris et al.
SCIENCE (2010)
Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin
Paola Magotti et al.
JOURNAL OF MOLECULAR RECOGNITION (2009)
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor
Suzan H. M. Rooijakkers et al.
NATURE IMMUNOLOGY (2009)
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators
Jin Wu et al.
NATURE IMMUNOLOGY (2009)
Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition
Bert J. C. Janssen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Factor B structure provides insights into activation of the central protease of the complement system
Fin J. Milder et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Structure of C3b reveals conformational changes that underlie complement activity
Bert J. C. Janssen et al.
NATURE (2006)
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin
Madan Katragadda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Structures of complement component C3 provide insights into the function and evolution of immunity
BJC Janssen et al.
NATURE (2005)
Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins
G Sfyroera et al.
JOURNAL OF IMMUNOLOGY (2005)
Design and NMR characterization of active analogues of compstatin containing non-natural amino acids
B Mallik et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Compstatin, a peptide inhibitor of complement, exhibits species-specific binding to complement component C3
A Sahu et al.
MOLECULAR IMMUNOLOGY (2003)
Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin
A Sahu et al.
JOURNAL OF IMMUNOLOGY (2000)