相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction
Jonathan M. Ellis et al.
NATURE CATALYSIS (2022)
Tryptophan Synthase: Biocatalyst Extraordinaire
Ella Watkins-Dulaney et al.
CHEMBIOCHEM (2021)
High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives
David G. McLaren et al.
SLAS DISCOVERY (2021)
Mapping enzyme catalysis with metabolic biosensing
Linfeng Xu et al.
NATURE COMMUNICATIONS (2021)
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19
John A. McIntosh et al.
ACS CENTRAL SCIENCE (2021)
macroMS: Image-Guided Analysis of Random Objects by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Kisurb Choe et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)
Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
Edward Kalkreuter et al.
NATURE COMMUNICATIONS (2021)
Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs
M. Eng. Qingyun Tang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
A mass spectrometry-based high-throughput screening method for engineering fatty acid synthases with improved production of medium-chain fatty acids
Pu Xue et al.
BIOTECHNOLOGY AND BIOENGINEERING (2020)
Development of GFP-based high-throughput screening system for directed evolution of glucose oxidase
Gordana Kovacevic et al.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2019)
A multi-substrate screening approach for the identification of a broadly applicable Diets-Alder catalyst
Hyejin Kim et al.
NATURE COMMUNICATIONS (2019)
Deciphering the Allosterically Driven Conformational Ensemble in Tryptophan Synthase Evolution
Miguel A. Maria-Solano et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection
Cassandra M. Joiner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Biocatalysis in Medicinal Chemistry: Challenges to Access and Drivers for Adoption
Nicole C. Goodwin et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Nitroalkanes as Versatile Nucleophiles for Enzymatic Synthesis of Noncanonical Amino Acids
David K. Romney et al.
ACS CATALYSIS (2019)
Design of an invitro biocatalytic cascade for the manufacture of islatravir
Mark A. Huffman et al.
SCIENCE (2019)
Engineering peptide ligase specificity by proteomic identification of ligation sites
Amy M. Weeks et al.
NATURE CHEMICAL BIOLOGY (2018)
Complete Switch of Reaction Specificity of an Aldolase by Directed Evolution In Vitro: Synthesis of Generic Aliphatic Aldol Products
Sebastian Junker et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
Andrew R. Buller et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform
Fuqiang Ma et al.
NATURE COMMUNICATIONS (2018)
Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues
Christina E. Boville et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules
Joerg H. Schrittwieser et al.
CHEMICAL REVIEWS (2018)
From molecular engineering to process engineering: development of high-throughput screening methods in enzyme directed evolution
Lidan Ye et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)
Enabling Biocatalysis by High-Throughput Protein Engineering Using Droplet Microfluidics Coupled to Mass Spectrometry
Xue W. Diefenbach et al.
ACS OMEGA (2018)
Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase
Richard Obexer et al.
NATURE CHEMISTRY (2017)
Profiling of Microbial Colonies for High-Throughput Engineering of Multistep Enzymatic Reactions via Optically Guided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Tong Si et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
David K. Romney et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Biocatalysis in the Pharmaceutical Industry: The Need for Speed
Matthew D. Truppo
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
Emily E. Wrenbeck et al.
NATURE COMMUNICATIONS (2017)
Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling
Mary C. Andorfer et al.
ACS CATALYSIS (2017)
Measuring specificity in multi-substrate/product systems as a tool to investigate selectivity in vivo
Yin-Ming Kuo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2016)
What are the Limitations of Enzymes in Synthetic Organic Chemistry?
Manfred T. Reetz
CHEMICAL RECORD (2016)
Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase
Michael Herger et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Directed evolution of RebH for catalyst-controlled halogenation of indole C-H bonds
Mary C. Andorfer et al.
CHEMICAL SCIENCE (2016)
In-Depth High-Throughput Screening of Protein Engineering Libraries by Split-GFP Direct Crude Cell Extract Data Normalization
Javier Santos-Aberturas et al.
CHEMISTRY & BIOLOGY (2015)
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
Andrew R. Buller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine
Brianna B. Williams et al.
CELL HOST & MICROBE (2014)
Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases
Irina Koryakina et al.
ACS CHEMICAL BIOLOGY (2013)
Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water
Svenja Staudt et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Reengineered carbonyl reductase for reducing methyl-substituted cyclohexanones
Andre Jakoblinnert et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2013)
Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols
Johann H. Sattler et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library
Anders G. Sandstrom et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity
Kaidong Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
Olga Khersonsky et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
Directed Evolution of an Enantioselective Lipase with Broad Substrate Scope for Hydrolysis of α-Substituted Esters
Karin Engstrom et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Christopher K. Savile et al.
SCIENCE (2010)
Improving catalytic function by ProSAR-driven enzyme evolution
Richard J. Fox et al.
NATURE BIOTECHNOLOGY (2007)
Protein stability promotes evolvability
JD Bloom et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Expanding the range of substrate acceptance of enzymes: Combinatorial active-site saturation test
MT Reetz et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Enzyme activity fingerprinting with substrate cocktails
JP Goddard et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Construction of stabilized proteins by combinatorial consensus mutagenesis
N Amin et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2004)
Higher-end serotonin receptors:: 5-HT5, 5-HT6, and 5-HT7
RA Glennon
JOURNAL OF MEDICINAL CHEMISTRY (2003)
分享论文
