4.8 Article

TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Tumor-targeted nanoparticles improve the therapeutic index of BCL2 and MCL1 dual inhibition

Neeta Bala Tannan et al.

Summary: Dual targeting of MCL1 and BCL2 proteins using S63845 and venetoclax induces durable remissions in DLBCL tumors in mice, but is accompanied by hematologic toxicity and weight loss. Encapsulation into nanoparticles targeting P-selectin reduces toxicity, enhances tumor drug enrichment, and allows for a reduction in drug dose.
Article Oncology

Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target

Florencia Palacios et al.

Summary: The research indicates that elevated levels of MSI2 in chronic lymphocytic leukemia are associated with poor prognosis and that its inhibition can eliminate leukemia cells. MSI2 may serve as a potential therapeutic target in CLL.

LEUKEMIA (2021)

Article Oncology

The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells

Luisa Klemke et al.

Summary: Research has found that different alleleic mutations of mutant p53 gene (mutp53) in pancreatic ductal adenocarcinoma (PDAC) have specific oncogenic functions, mainly promoting invasion and metastasis to drive tumor progression. Similar to colorectal cancer (CRC), specific alleles of mutp53 exert enhanced functions by binding to and hyperactivating STAT3. This discovery suggests potential therapeutic vulnerabilities in targeting GOF mutp53 proteins in PDAC.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling

Weiwei Sheng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Multidisciplinary Sciences

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

Diu T. T. Nguyen et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

PRMT5 function and targeting in cancer

Hyungsoo Kim et al.

CELL STRESS (2020)

Article Biochemistry & Molecular Biology

PRMT1 loss sensitizes cells to PRMT5 inhibition

Guozhen Gao et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Gerard Minuesa et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Steffen Boettcher et al.

SCIENCE (2019)

Article Biochemistry & Molecular Biology

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

Aliaksandra Radzisheuskaya et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis

Yan Stein et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

PRMT5 is essential for B cell development and germinal center dynamics

Ludivine C. Litzler et al.

NATURE COMMUNICATIONS (2019)

Review Oncology

Targeting the Bcl-2 Family in B Cell Lymphoma

Clare M. Adams et al.

FRONTIERS IN ONCOLOGY (2019)

Article Genetics & Heredity

Mutational processes shape the landscape of TP53 mutations in human cancer

Andrew O. Giacomelli et al.

NATURE GENETICS (2018)

Article Multidisciplinary Sciences

NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death

Yuxuan Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

Madhumitha Rengasamy et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

Protein Methyltransferases: A Distinct, Diverse, and Dynamic Family of Enzymes

P. Ann Boriack-Sjodin et al.

BIOCHEMISTRY (2016)

Article Chemistry, Medicinal

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

Kenneth W. Duncan et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

Article Medicine, General & Internal

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

Andrew W. Roberts et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

James Taggart et al.

NATURE COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Myc and cell cycle control

Gabriel Bretones et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)

Article Cell & Tissue Engineering

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

Hyog Young Kwon et al.

CELL STEM CELL (2015)

Article Medicine, Research & Experimental

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program

Sun-Mi Park et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Medicine, Research & Experimental

Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

Fan Liu et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Oncology

Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia

Jaspal Kaeda et al.

LEUKEMIA & LYMPHOMA (2015)

Article Biochemistry & Molecular Biology

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre et al.

NATURE CHEMICAL BIOLOGY (2015)

Review Oncology

Ki67 is a promising molecular target in the diagnosis of cancer

Lian Tao Li et al.

MOLECULAR MEDICINE REPORTS (2015)

Article Biochemistry & Molecular Biology

PRMT5 is essential for the eIF4E-mediated 5′-cap dependent translation

Ji-Hong Lim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

A Conserved Three-nucleotide Core Motif Defines Musashi RNA Binding Specificity

N. Ruth Zearfoss et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Immunology

Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs

Sun-Mi Park et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Review Cell Biology

Mutant p53: one name, many proteins

William A. Freed-Pastor et al.

GENES & DEVELOPMENT (2012)

Article Biochemistry & Molecular Biology

Camera: a competitive gene set test accounting for inter-gene correlation

Di Wu et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

Crystal structure of the human PRMT5:MEP50 complex

Stephen Antonysamy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

Takahiro Ito et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

Michael G. Kharas et al.

NATURE MEDICINE (2010)

Article Cell Biology

Mutant p53 Gain-of-Function in Cancer

Moshe Oren et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Cell Biology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

Magali Olivier et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Cell Biology

Arginine methylation regulates the p53 response

Martin Jansson et al.

NATURE CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma

Sharmistha Pal et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs

G Meister et al.

EMBO JOURNAL (2002)