4.8 Article

Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors

Franziska Nadler et al.

Summary: The translation process in mitochondria, especially focusing on termination, recycling, and rescue mechanisms of mitoribosomes, is essential for maintaining cellular homoeostasis. Mitochondrial ribosomes are highly specialized in synthesizing core subunits of oxidative phosphorylation complexes, originated from bacterial ancestors but with substantial differences due to their endosymbiotic environment.

RNA BIOLOGY (2022)

Article Biochemistry & Molecular Biology

An in vitro system to silence mitochondrial gene expression

Luis Daniel Cruz-Zaragoza et al.

Summary: The study introduces a novel in vitro system to silence translation in mitochondria, shedding light on mechanisms of mitochondrial gene expression including ribosome/mRNA engagement and the recruitment of assembly factors by nascent chains. The research also reveals an unexpected role of the cytosolic oncofetal IGF2BP1 in mitochondrial translation.
Article Biochemistry & Molecular Biology

Structural basis of translation termination, rescue, and recycling in mammalian mitochondria

Eva Kummer et al.

Summary: The mitochondrial translation system, derived from a bacterial ancestor, has diverged significantly during evolution. Using single-particle cryo-electron microscopy, researchers identified mitochondrial translation termination mechanisms in molecular detail. Mitochondrial release factor 1a and peptidyl-tRNA hydrolase ICT1 play crucial roles in mitochondrial protein synthesis.

MOLECULAR CELL (2021)

Article Multidisciplinary Sciences

Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

Hauke S. Hillen et al.

Summary: The study elucidates the mechanism of GTPase-driven maturation of the human mitochondrial large ribosomal subunit (mtLSU) using endogenous complex purification, in vitro reconstitution and cryo-EM. It reveals how biogenesis factors like GTPBP5, MTERF4, and NSUN4 facilitate the folding of the peptidyl transferase center (PTC). The research also demonstrates the dual-role of GTPBP6 in ribosome biogenesis and recycling through structural analysis of mature mitochondrial ribosomes treated with GTPBP6.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Mechanism of ribosome rescue by alternative ribosome-rescue factor B

Kai-Hsin Chan et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes

Elena Lavdovskaia et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Multidisciplinary Sciences

Elongational stalling activates mitoribosome-associated quality control

Nirupa Desai et al.

SCIENCE (2020)

Review Biochemistry & Molecular Biology

Leigh syndrome in a patient with a novel C12orf65 pathogenic variant: case report and literature review

Eduardo Perrone et al.

GENETICS AND MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis

Elena Lavdovskaia et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Cell Biology

The Enigma of the Respiratory Chain Supercomplex

Dusanka Milenkovic et al.

CELL METABOLISM (2017)

Article Biochemistry & Molecular Biology

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

Ricarda Richter-Dennerlein et al.

Article Multidisciplinary Sciences

Structural basis for stop codon recognition in eukaryotes

Alan Brown et al.

NATURE (2015)

Review Cell Biology

Integrating mitochondrial translation into the cellular context

Ricarda Richter-Dennerlein et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Genetics & Heredity

Mutations in C12orf62, a Factor that Couples COX I Synthesis with Cytochrome c Oxidase Assembly, Cause Fatal Neonatal Lactic Acidosis

Woranontee Weraarpachai et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2012)

Article Genetics & Heredity

Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect

Hana Antonicka et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2010)

Article Biochemistry & Molecular Biology

A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome

Ricarda Richter et al.

EMBO JOURNAL (2010)

Article Multidisciplinary Sciences

Hungry Codons Promote Frameshifting in Human Mitochondrial Ribosomes

Richard Temperley et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Structural basis for translation termination on the 70S ribosome

Martin Laurberg et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

The human mitochondrial ribosome recycling factor is essential for cell viability

Joanna Rorbach et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Multidisciplinary Sciences

Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome

Albert Weixlbaumer et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

Two distinct components of release factor function uncovered by nucleophile partitioning analysis

Jeffrey J. Shaw et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

mtRF1a is a human mitochondrial translation release factor decoding the major termination Codons UAA and UAG

Hamid Reza Soleimanpour-Lichaei et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

Respiratory chain supercomplexes set the threshold for respiration defects in human mtDNA mutant cybrids

Marilena D'Aurelio et al.

HUMAN MOLECULAR GENETICS (2006)

Article Multidisciplinary Sciences

A tripeptide 'anticodon' deciphers stop codons in messenger RNA

K Ito et al.

NATURE (2000)