4.8 Article

Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+breast tumors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues

Eiman Elwakeel et al.

Summary: Activation of the tumor-associated stroma and the role of cancer-associated fibroblasts (CAFs) in shaping tumor development are crucial in breast cancer. Understanding the multiple functions of CAFs and developing intervention strategies are important for improving breast cancer therapy. Further research is needed to identify specific subsets of CAFs that can be targeted for therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Cell Biology

Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy

Jenniffer Linares et al.

Summary: Multiple lines of evidence suggest that cancer development and malignant progression are influenced not only by cancer cell-autonomous processes but also by interactions with the tumor microenvironment, particularly through cancer-associated fibroblasts (CAFs) that regulate key mechanisms during metastasis and treatment response. Recent advances in CAFs biology highlight the potential of CAFs-secreted factors as druggable targets and biomarkers for cancer diagnosis and prognosis, paving the way for further research and clinical applications.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

News Item Biotechnology & Applied Microbiology

Restoring IL-2 to its cancer immunotherapy glory

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Multidisciplinary Sciences

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

Jerod L. Ptacin et al.

Summary: The application of synthetic biology in medicine has the potential to revolutionize drug development, with engineered semi-synthetic organisms offering a new approach to creating chemically modified biologics. Through targeted chemical modifications in human IL-2, a variant named THOR-707 has been identified that shows selective engagement with IL-2 receptors, leading to enhanced immune responses in mice and significant reduction in tumor growth in preclinical models.

NATURE COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy

Inja Waldhauer et al.

Summary: FAP-IL2v is a potent immunocytokine that enhances the efficacy of different T- and NK-cell-based cancer immunotherapies by stimulating antibody activity and promoting tumor targeting.
Letter Biochemistry & Molecular Biology

A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome

Weiqi Hong et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Oncology

Tumor-Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation

Patricia Fernandez-Nogueira et al.

CLINICAL CANCER RESEARCH (2020)

Article Oncology

Reactive stroma and trastuzumab resistance in HER2-positive early breast cancer

Amir Sonnenblick et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Editorial Material Oncology

Improving the outcomes of checkpoint inhibitors in breast cancer

George E. Peoples

LANCET ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

The emerging roles of inflammasome-dependent cytokines in cancer development

Hanne Van Gorp et al.

EMBO REPORTS (2019)

Article Biochemistry & Molecular Biology

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

Uku Raudvere et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Nadim Aizarani et al.

NATURE (2019)

Review Medicine, Research & Experimental

Principles and approaches for reproducible scoring of tissue stains in research

David K. Meyerholz et al.

LABORATORY INVESTIGATION (2018)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Article Oncology

Immunotherapy for Breast Cancer: What Are We Missing?

Robert H. Vonderheide et al.

CLINICAL CANCER RESEARCH (2017)

Article Cell Biology

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

Ian B. Robertson et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Review Oncology

Clinical significance of tumor-infiltrating lymphocytes in breast cancer

Sasha E. Stanton et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)

Review Oncology

The biology and function of fibroblasts in cancer

Raghu Kalluri

NATURE REVIEWS CANCER (2016)

Article Genetics & Heredity

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

Alexandre Calon et al.

NATURE GENETICS (2015)

Article Oncology

Advances and Future Directions in the Targeting of HER2-positive Breast Cancer: Implications for the Future

Ishwaria M. Subbiah et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Multidisciplinary Sciences

Inferring tumour purity and stromal and immune cell admixture from expression data

Kosuke Yoshihara et al.

NATURE COMMUNICATIONS (2013)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Biochemistry & Molecular Biology

Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression

Brian F. Zamarron et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)

Article Immunology

Stimulated γδ T Cells Increase the In Vivo Efficacy of Trastuzumab in HER-2+ Breast Cancer

Aude-Helene Capietto et al.

JOURNAL OF IMMUNOLOGY (2011)

Article Medicine, General & Internal

Adjuvant Trastuzumab in HER2-Positive Breast Cancer

Dennis Slamon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

Review Medicine, General & Internal

Drug therapy: Trastuzumab - Mechanism of action and use in clinical practice

Clifford A. Hudis

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Review Oncology

Fibroblasts in cancer

R Kalluri et al.

NATURE REVIEWS CANCER (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)