[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

The development of new classes of isosteres and building blocks is crucial to the advancement of medicinal chemistry programs. Here, the authors report the synthesis and development of ladderanes to act as replacements for meta-substituted aromatic rings and cyclohexanes. Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synthesis of the building blocks is presented along with representative derivatization. Preliminary studies reveal that the [2]-ladderanes offer similar metabolic and physicochemical properties thus establishing this class of molecules as interesting motifs.

Automated summary

The authors report the synthesis and development of ladderanes as replacements for meta-substituted aromatic rings and cyclohexanes. These compounds offer similar metabolic and physicochemical properties, establishing them as interesting motifs for drug discovery.