相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
Robert L. Summers et al.
CELL CHEMICAL BIOLOGY (2022)
Bright and stable luminescent probes for target engagement profiling in live cells
N. Connor Payne et al.
NATURE CHEMICAL BIOLOGY (2021)
Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials
Maelle Duffey et al.
TRENDS IN PARASITOLOGY (2021)
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors
Masanori Okaniwa et al.
ACS INFECTIOUS DISEASES (2021)
Prioritization of Molecular Targets for Antimalarial Drug Discovery
Barbara Forte et al.
ACS INFECTIOUS DISEASES (2021)
High-Throughput Screening: today's biochemical and cell-based approaches
Vincent Blay et al.
DRUG DISCOVERY TODAY (2020)
The antimalarial resistome - finding new drug targets and their modes of action
Krypton Carolino et al.
CURRENT OPINION IN MICROBIOLOGY (2020)
Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs
Michael D. Shultz
JOURNAL OF MEDICINAL CHEMISTRY (2019)
The Adaptive Proline Response in P-falciparum Is Independent of PfeIK1 and eIF2α Signaling
Lola Fagbami et al.
ACS INFECTIOUS DISEASES (2019)
Aminoacyl-tRNA synthetases as therapeutic targets
Nam Hoon Kwon et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses
Jesse Hwang et al.
ANTIVIRAL RESEARCH (2019)
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model
Rebecca E. K. Mandt et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis
Paul Schimmel
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases
Jiwon Kong et al.
SLAS DISCOVERY (2018)
Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing
Kenneth Yin Zhang et al.
CHEMICAL REVIEWS (2018)
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Annie N. Cowell et al.
SCIENCE (2018)
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
Stephen Nakazawa Hewitt et al.
ACS INFECTIOUS DISEASES (2017)
A new set of assays for the discovery of aminoacyl-tRNA synthetase inhibitors
Adelaide Saint-Leger et al.
METHODS (2017)
Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy
Akira Shibata et al.
PLOS ONE (2017)
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Vitul Jain et al.
STRUCTURE (2017)
An asymmetric synthesis of febrifugine, halofuginone and hemiketal isomers
Shaun Smullen et al.
TETRAHEDRON (2017)
Antimalarial Drug Resistance: A Threat to Malaria Elimination
Didier Menard et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation
Takeo Arita et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with L-proline
Ryutaro Adachi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Time-Resolved Fluorescence Resonance Energy Transfer [TR-FRET] Assays for Biochemical Processes
Ekin Ergin et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
Jonathan D. Herman et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis
Vitul Jain et al.
STRUCTURE (2015)
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase
Pengfei Fang et al.
NATURE COMMUNICATIONS (2015)
ATP-Mediated Kinome Selectivity: The Missing Link in Understanding the Contribution of Individual JAK Kinase Isoforms to Cellular Signaling
Atli Thorarensen et al.
ACS CHEMICAL BIOLOGY (2014)
The chemistry and biology of febrifugine and halofuginone
Noel P. McLaughlin et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria
Jonathan D. Herman et al.
GENOME BIOLOGY (2014)
Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings
Violeta Yu et al.
EXPERIMENTAL HEMATOLOGY (2013)
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
Huihao Zhou et al.
NATURE (2013)
Essential nontranslational functions of tRNA synthetases
Min Guo et al.
NATURE CHEMICAL BIOLOGY (2013)
A Spectrophotometric Assay for Quantitative Measurement of Aminoacyl-tRNA Synthetase Activity
Igor Cestari et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Characterization of Plasmodium Liver Stage Inhibition by Halofuginone
Emily R. Derbyshire et al.
CHEMMEDCHEM (2012)
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Tracy L. Keller et al.
NATURE CHEMICAL BIOLOGY (2012)
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds
Emily R. Derbyshire et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis
Benjamin P. Duckworth et al.
CHEMISTRY & BIOLOGY (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Ligand binding assays at equilibrium: validation and interpretation
Edward C. Hulme et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
Aaron McKenna et al.
GENOME RESEARCH (2010)
xia2: an expert system for macromolecular crystallography data reduction
G. Winter
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2010)
East meets West: how China almost cured malaria
William R. Burns
ENDEAVOUR (2008)
A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities
Kirk Beebe et al.
ANALYTICAL BIOCHEMISTRY (2007)
Antimalarial activities and therapeutic properties of febrifugine analogs
SP Jiang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)