期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-33924-3
关键词
-
资金
- National Natural Science Foundation of China [22231001, 21971023, 22177014]
This study presents a supramolecular strategy to prepare Type-I photodynamic agents by introducing electron acceptors to existing Type-II photosensitizers. These photodynamic agents possess hypoxia tolerance and can generate strong oxidizing cationic radicals and superoxide radicals through photo-induced electron transfer. They show promising potential in tumor treatment with an oxygen-independent mechanism.
Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare Type-I PSs is of great importance, but remains a challenge. Here, we report a supramolecular strategy for the preparation of Type-I photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors to the existing Type-II PSs. As a proof-of-concept, three electron acceptors were designed and co-assembled with a classical PS to produce quadruple hydrogen-bonded supramolecular photodynamic agents. The photo-induced electron transfer from the PS to the adjacent electron acceptor occurs efficiently, leading to the generation of a strong oxidizing PS+center dot and an anionic radical of the acceptor, which further transfers an electron to oxygen to form O-2(-center dot). In addition, these photodynamic agents induce direct photocatalytic oxidation of NADH with a turnover frequency as high as 53.7 min(-1), which offers an oxygen-independent mechanism to damage tumors.
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