期刊
EPIGENOMICS
卷 14, 期 20, 页码 1281-1304出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2022-0239
关键词
cancer; cardiovascular diseases; diet; epigenetics; inflammatory skin diseases; neurobehavioral disorders; neurodegenerative diseases; obesity and Type 2 diabetes
资金
- Fondazione Umberto Veronesi
- European Union [896865]
- Department of Medical Sciences, Turin University
- Italian Ministry for Education, University and Research (Ministero dell'Istruzione, dell'Universitae della Ricerca-MIUR) [D15D18000410001]
- Marie Curie Actions (MSCA) [896865] Funding Source: Marie Curie Actions (MSCA)
Dietary factors can regulate epigenetic processes and contribute to the onset and progression of complex diseases.
Dietary factors can regulate epigenetic processes during life, modulating the intracellular pools of metabolites necessary for epigenetic reactions and regulating the activity of epigenetic enzymes. Their effects are strong during the prenatal life, when epigenetic patterns are written, allowing organogenesis. However, interactions between diet and the epigenome continue throughout life and likely contribute to the onset and progression of various complex diseases. Here, we review the contribution of dietary factors to the epigenetic changes observed in complex diseases and suggest future steps to better address this issue, focusing on neurobehavioral, neuropsychiatric and neurodegenerative disorders, cardiovascular diseases, obesity and Type 2 diabetes, cancer and inflammatory skin diseases.
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