期刊
EPIGENOMICS
卷 14, 期 19, 页码 -出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2022-0179
关键词
artificial neural networks; ASD; autism spectrum disorder; DNA methylation; epigenetics; maternal risk factors; sex difference
资金
- University of Pisa Research Project [PRA 2017 61]
- IRCCS Fondazione Stella Maris
- IRCCS Fondazione Stella Maris ('5 X 1000' voluntary contributions, Italian Ministry of Health) [2774203]
This study used artificial neural networks to examine the connections among blood gene methylation levels, sex, maternal risk factors, and symptom severity in children with autism spectrum disorder (ASD). The results showed that the methylation levels of MECP2, HTR1A, and OXTR genes were associated with females, while the methylation levels of EN2, BCL2, and RELN genes were associated with males. High gestational weight gain, lack of folic acid supplements, advanced maternal age, preterm birth, low birthweight, and living in a rural context were the best predictors of a high ADOS-2 score.
Aim and methods: Artificial neural networks were used to unravel connections among blood gene methylation levels, sex, maternal risk factors and symptom severity evaluated using the Autism Diagnostic Observation Schedule 2 (ADOS-2) score in 58 children with autism spectrum disorder (ASD). Results: Methylation levels of MECP2, HTR1A and OXTR genes were connected to females, and those of EN2, BCL2 and RELN genes to males. High gestational weight gain, lack of folic acid supplements, advanced maternal age, preterm birth, low birthweight and living in rural context were the best predictors of a high ADOS-2 score. Conclusion: Artificial neural networks revealed links among ASD maternal risk factors, symptom severity, gene methylation levels and sex differences in methylation that warrant further investigation in ASD.
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