The effect of vitreomacular interface in neovascular age-related macular degeneration treated with intravitreal injection of anti-VEGF

Review Pharmacology & Pharmacy

Emerging therapies and their delivery for treating age-related macular degeneration

Chloe N. Thomas et al.

Summary: Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world, with the need for new therapies to address disease progression and treatment challenges at different stages.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹

Article Ophthalmology

Corneal Nerve Fiber and Sensitivity Loss After Repeated Intravitreal Anti-VEGF Injections: An In Vivo Confocal Microscopy Study

Osman Ahmet Polat et al.

Summary: This study investigated the corneal sensation, subbasal nerve plexus (SBNP), and ocular surface symptoms in patients who received multiple intravitreal anti-VEGF injections for AMD and DME. The results showed that the corneal nerve fiber density and corneal sensitivity were significantly decreased, while the OSDI scores were increased in these patients.

CORNEA (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Safety review of anti-VEGF therapy in patients with myopic choroidal neovascularization

Danny S. C. Ng et al.

Summary: Anti-VEGF therapy with currently available drugs generally has favorable safety outcomes in the short-term for myopic CNV, but ocular adverse events such as worsening myopic traction maculopathy, increased risk of retinal detachment, and progression of chorioretinal atrophy may develop following the treatment. Clinicians should be aware of these potential complications and evaluate them before and after anti-VEGF therapy.

EXPERT OPINION ON DRUG SAFETY (2022)

添加到收藏夹

Article Engineering, Biomedical

Structure and mechanics of the vitreoretinal interface

Joseph D. Phillips et al.

Summary: Vitreoretinal mechanics play a crucial role in retinal trauma and various sight-threatening diseases. However, the understanding of the mechanics at the vitreoretinal interface is limited, and further research is needed to fill the knowledge gaps in this field. Studying the structure and function of vitreoretinal adhesion can provide valuable insights into disease treatments.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Sphingosine-1-phosphate expression in human epiretinal membranes

Minho Kim et al.

Summary: Abnormal posterior vitreous detachment (PVD) is speculated to be an important mechanism in the development of epiretinal membrane (ERM). Sphingosine-1-phosphate (S1P) has been found to be expressed in ERM specimens, indicating its potential role in the pathogenesis of ERM during abnormal PVD.

PLOS ONE (2022)

添加到收藏夹

Article Ophthalmology

Switching anti-VEGF agent for wet AMD: evaluation of impact on visual acuity, treatment frequency and retinal morphology in a real-world clinical setting

Elisabet Granstam et al.

Summary: This cross-sectional real-world study aimed to evaluate the impact of switching anti-VEGF agent from ranibizumab to aflibercept in eyes with ongoing chronic treatment for wet AMD. The study found that while visual acuity remained stable, treatment frequency decreased, and retinal morphology improved after 12 months of switching.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2021)

添加到收藏夹

Article Ophthalmology

Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

Hikari Taniguchi et al.

Summary: The study suggests that anti-VEGF injections alone do not cause the development of ERMs, VMA or PVD may have a prior impact on the development of ERMs in ARMD, and peripheral retinal degenerations and vitreomacular adhesion are related to the development of ERMs and the pathogenesis of ARMD.

BMC OPHTHALMOLOGY (2021)

添加到收藏夹

Article Ophthalmology