期刊
JOURNAL OF FUNCTIONAL FOODS
卷 96, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2022.105221
关键词
Crocin; Oxidative stress; Inflammation; Intestinal barrier; Gut microbiota; Atherosclerosis
资金
- Scientific and Technological Projects of Suzhou City [SYS2018022]
- Scientific Research Foundation for Scholars of HZNU [2022QDL004]
- Natural Science Foun-dation of Zhejiang Province [LY19H260002]
This study found that crocin can reduce the progression of atherosclerosis by enhancing hepatic antioxidant capacity, inhibiting NLRP3 inflammasome and TLR4 signal, and improving gut microbiota composition.
Crocin has a protective effect on neurodegenerative disease, but whether crocin can prevent atherosclerosis remains unclear. The present study aimed to explore the possible anti-atherosclerotic mechanism of crocin in LDLR-/-mice. Mice were fed an atherogenic high-fat/cholesterol diet and concomitantly treated by intragastric administration with normal saline (Model) or 20 or 40 mg/(kg.bw.day) crocin for 8 weeks. Pathological results showed that Model group exhibited a marked atherosclerotic plaque, while crocin significantly reduced atherosclerotic plaque, accompanied by a small amount of denatured collagen fiber and foam cells. Mechanis-tically, crocin, especially high-dose suppressed the formation of atherosclerotic plaques via enhancing hepatic antioxidant capacity. Besides, crocin effectively inhibited NLRP3 inflammasome and blocked TLR4 signal, through reducing oxidative stress based on Nrf2/Keap1 pathway, and increasing intestinal tight junction proteins and improving gut microbiota composition. These results suggest that crocin can ameliorate inflammation and attenuate atherosclerotic progression by oxidative stress reduction and intestinal barrier improvement.
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