期刊
JOURNAL OF FUNCTIONAL FOODS
卷 97, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2022.105252
关键词
Astaxanthin-rich extract derived from; Paracoccus carotinifaciens; Reactive oxygen species; Mitochondrial superoxide; Glucose -stimulated insulin secretion
资金
- ENEOS Corporation
This study evaluated the antidiabetic effect of an astaxanthin-rich extract (ARE) derived from Paracoccus carotinifaciens on pancreatic beta cells. The extract was found to increase insulin secretion and protect against cell death, potentially through the control of mitochondrial superoxide production.
Astaxanthin is a natural pigment that is used as a dietary supplement. Many experiments have shown that astaxanthin has positive effects against various diseases including diabetes. Adonixanthin and adonirubin are biosynthetic intermediates of beta-carotene to astaxanthin and possess the same radical scavenging activity as astaxanthin. In this study, we evaluated the antidiabetic effect on pancreatic beta cells of astaxanthin-rich extract (ARE) derived from Paracoccus carotinifaciens, which contains several carotenoids such as astaxanthin, adonir-ubin, and adonixanthin. Specifically, we studied the effects on insulin secretion and cytoprotection as well as on intracellular reactive oxygen species (ROS) generation and mitochondrial superoxide production. As a result, pretreatment with ARE derived from P. carotinifaciens increased insulin secretion under the condition of 20 mM glucose stimulation in iGL cells. In addition, ARE derived from P. carotinifaciens significantly decreased strep-tozotocin (STZ)-induced cell death in INS-1 cells, and isobologram analysis revealed the synergistic effects among astaxanthin, adonixanthin, and adonirubin. We clarified that the production control of mitochondrial superoxide was involved in the mechanism of these effects. These findings suggest that ARE derived from P. carotinifaciens may be used to treat diabetes by increasing glucose-stimulated insulin secretion and protecting pancreatic beta cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据