Association of MTHFR 677C>T polymorphism with pregnancy outcomes in IVF/ICSI-ET recipients with adequate synthetic folic acid supplementation

Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphism rs1801133 (677C 0.001) and BMI (OR = 0.95, 95% CI = 0.90, 0.997, P = 0.037). In 349 clinically pregnant women, no association of the MTHFR 677C T with pregnancy outcomes was found in the additive model, dominant model, or recessive model. Of the 273 women with positive pregnancy outcomes, 34 had a preterm delivery. MTHFR 677C>T was not associated with a preterm delivery after adjusting for age and BMI. The current results indicated that MTHFR polymorphism rs1801133 was not related to the pregnancy rate or pregnancy outcomes of women undergoing IVF/ICSI-ET with adequate synthetic FA supplementation, suggesting that simple supplementation with less expensive and readily available FA, rather than expensive 5-MTHF, appeared to be appropriate.

Automated summary

This study found an association between MTHFR genetic polymorphism rs1801133 and BMI, but not with pregnancy outcomes. Additionally, MTHFR 677C>T was not associated with preterm delivery. The results suggest that using less expensive and readily available folic acid supplementation may be appropriate in women undergoing IVF/ICSI-ET with adequate synthetic folic acid supplementation.