期刊
FRONTIERS IN NEURAL CIRCUITS
卷 16, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2022.984802
关键词
epileptiform synchronization; excitatory transmission; GABA(A) receptor; inhibitory transmission; interictal spikes; mesial temporal lobe epilepsy; seizures
资金
- Canadian Institutes of Health Research [PJT153310, PJT166178, MOP130328]
- Savoy Foundation
- Italian Ministry of Health [RF 2018-12365681]
- Paolo Zorzi Association for Neuroscience
- CURE
Under physiological conditions, neuronal network synchronization can lead to specific EEG patterns related to behavioral and cognitive functions. However, excessive synchronization can cause epileptic activities. Experimental studies have found that GABA(A) signaling plays a paradoxical role in generating interictal discharges and initiating focal seizures. There is also evidence suggesting its involvement in epileptogenesis.
Under physiological conditions, neuronal network synchronization leads to different oscillatory EEG patterns that are associated with specific behavioral and cognitive functions. Excessive synchronization can, however, lead to focal or generalized epileptiform activities. It is indeed well established that in both epileptic patients and animal models, focal epileptiform EEG patterns are characterized by interictal and ictal (seizure) discharges. Over the last three decades, employing in vitro and in vivo recording techniques, several experimental studies have firmly identified a paradoxical role of GABA(A) signaling in generating interictal discharges, and in initiating-and perhaps sustaining-focal seizures. Here, we will review these experiments and we will extend our appraisal to evidence suggesting that GABA(A) signaling may also contribute to epileptogenesis, i.e., the development of plastic changes in brain excitability that leads to the chronic epileptic condition. Overall, we anticipate that this information should provide the rationale for developing new specific pharmacological treatments for patients presenting with focal epileptic disorders such as mesial temporal lobe epilepsy (MTLE).
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