期刊
VIRUSES-BASEL
卷 14, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v14102097
关键词
influenza; vaccination; indirect protection
类别
资金
- Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau of the Hong Kong SAR Government [CHP-CE-03]
- Hong Kong Government [T11-712/19N]
- Health and Medical Research Fund, Food and Health Bureau, Government of the Hong Kong Special Administrative Region [05190097]
- Laboratory of Excellence Integrative Biology of Emerging Infectious Diseases
Influenza vaccination is crucial in preventing influenza virus infection, yet it offers limited indirect protection in the case of influenza B epidemic in Hong Kong. By analyzing six influenza A epidemics, it was found that community, rather than households, served as the main source of infection, with only 10% of cases attributed to household transmission.
Influenza vaccination is an important intervention to prevent influenza virus infection. Our previous analysis suggested that indirect protection is limited in an influenza B epidemic in Hong Kong. We further analyzed six influenza A epidemics to determine such potential. We applied a statistical model to estimate household transmission dynamics in the 3 influenza A(H3N2) and 3 pandemic influenza A(H1N1) epidemics. Then, we estimated the reduction in infection risk among unvaccinated household members when all children in households are vaccinated, with different assumptions on vaccine efficacy (VE). In the optimal scenario that VE was 70%, the reduction to the total probability of infection was only marginal, with relative probabilities ranged from 0.91-0.94 when all children in households were vaccinated because community was by far the main source of infection during the six epidemics in our study. The proportion of cases attributed to household transmission was 10% (95% CrI: 7%, 13%). Individual influenza vaccination is important even when other household members are vaccinated, given the degree of indirect protection is small.
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