期刊
VIRUSES-BASEL
卷 14, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v14102154
关键词
usnic acid; virus SARS-CoV-2; main viral protease 3CLPro; surface glycoprotein S; molecular modeling; antiviral compound
类别
资金
- Russian Science Foundation [22-23-00618]
A series of usnic acid derivatives were synthesized and tested for their antiviral activity against SARS-CoV-2 virus. Specific derivatives showed high activity against different strains of the virus. The study also revealed that the derivatives bind to the surface glycoprotein of the virus and provided insights into the possible antiviral mechanism.
In order to test the antiviral activity, a series of usnic acid derivatives were synthesized, including new, previously undescribed compounds. The activity of the derivatives against three strains of SARS-CoV-2 virus was studied. To understand the mechanism of antiviral action, the inhibitory activity of the main protease of SARS-CoV-2 virus was studied using the developed model as well as the antiviral activity against the pseudoviral system with glycoprotein S of SARS-CoV-2 virus on its surface. It was shown that usnic acid exhibits activity against three strains of SARS-CoV-2 virus: Wuhan, Delta, and Omicron. Compounds 10 and 13 also showed high activity against the three strains. The performed biological studies and molecular modeling allowed us to assume that the derivatives of usnic acid bind in the N-terminal domain of the surface glycoprotein S at the binding site of the hemoglobin decay metabolite.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据