期刊
VIRUSES-BASEL
卷 14, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v14102141
关键词
influenza virus; sialic acids; host specificity
类别
资金
- National Key R&D Program of China [2021YFD1800202]
- Chinese Universities Scientific Fund [2022RC019]
- Postgraduate Independent Innovation Research Fund Project of China Agricultural University [2022TC163]
Influenza viruses utilize sialic acid receptors to invade host cells, and factors such as sialic acid variants, glycan structural differences, and sulfation/fucosylation affect the specificity of viral host binding. Understanding these factors can contribute to the investigation of cross-species transmission of influenza viruses and the development of antiviral drugs.
Influenza viruses need to use sialic acid receptors to invade host cells, and the alpha-2,3 and alpha-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species transmission of the influenza viruses. The development of methods to detect the binding of influenza virus HA proteins to sialic acid receptors, as well as the development of glycobiological techniques, has led to a richer understanding of the structure of the sialylated glycan in influenza virus hosts. It was found that, in addition to the sialic acid glycosidic bond, sialic acid variants, length of the sialylated glycan, Gal-GlcNAc-linked glycosidic bond within the sialylated glycan, and sulfation/fucosylation of the GlcNAc within the sialylated glycan all affect the binding properties of influenza viruses to the sialic acid receptors, thus indirectly affecting the host specificity of influenza viruses. This paper will review the sialic acid variants, internal structural differences of sialylated glycan molecules that affect the host specificity of influenza viruses, and distribution characteristics of sialic acid receptors in influenza virus hosts, in order to provide a more reliable theoretical basis for the in-depth investigation of cross-species transmission of influenza viruses and the development of new antiviral drugs.
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