期刊
VIRUSES-BASEL
卷 14, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/v14092012
关键词
monkeypox; transmission; outbreak; atypical presentation
类别
资金
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health (NIH)
This article discusses the current monkeypox outbreak in non-endemic countries based on relevant research on monkeypox and smallpox. Undetected circulation, atypical transmission routes, and mild/asymptomatic cases have facilitated the spread of monkeypox in non-endemic regions. Therefore, improved diagnostics, enhanced surveillance, targeted education, and a better understanding of transmission routes are critical to controlling the current outbreak.
An ongoing monkeypox outbreak in non-endemic countries has resulted in the declaration of a public health emergency of international concern by the World Health Organization (WHO). Though monkeypox has long been endemic in regions of sub-Saharan Africa, relatively little is known about its ecology, epidemiology, and transmission. Here, we consider the relevant research on both monkeypox and smallpox, a close relative, to make inferences about the current outbreak. Undetected circulation combined with atypical transmission and case presentation, including mild and asymptomatic disease, have facilitated the spread of monkeypox in non-endemic regions. A broader availability of diagnostics, enhanced surveillance, and targeted education, combined with a better understanding of the routes of transmission, are critical to identify at-risk populations and design science-based countermeasures to control the current outbreak.
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