期刊
VIRUSES-BASEL
卷 14, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/v14091896
关键词
lipids; virus; virus-host interaction; cholesterol; metabolism
类别
资金
- Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of Slovak Republic
- Slovak Academy of Sciences [2/0030/19]
Through millions of years of co-evolution with their hosts, viruses have developed mechanisms to evade cellular defenses and use cellular pathways for replication. Lipids play a crucial role in viral replication, as viruses interact with and manipulate cellular membranes and lipid metabolism to create an optimal replication environment.
Over the millions of years-long co-evolution with their hosts, viruses have evolved plenty of mechanisms through which they are able to escape cellular anti-viral defenses and utilize cellular pathways and organelles for replication and production of infectious virions. In recent years, it has become clear that lipids play an important role during viral replication. Viruses use cellular lipids in a variety of ways throughout their life cycle. They not only physically interact with cellular membranes but also alter cellular lipid metabolic pathways and lipid composition to create an optimal replication environment. This review focuses on examples of how different viruses exploit cellular lipids in different cellular compartments during their life cycles.
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