☆ 4.3 Review

SARS-CoV-2 does not infect pigs, but this has to be verified regularly

XENOTRANSPLANTATION (2022)

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Article Biochemistry & Molecular Biology

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

Matthew Gagne et al.

Summary: mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta decreases over time, and protection may be dependent on anamnestic antibody responses. The vaccine provides durable but delayed protection in the lungs, while a boost may be needed for rapid and sustained protection in the upper and lower airways.

CELL (2022)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection in free-ranging white-tailed deer

Vanessa L. Hale et al.

Summary: Research shows that free-ranging white-tailed deer in northeast Ohio, USA are highly susceptible to SARS-CoV-2 infection, potentially enabling the virus to be transmitted in wildlife, opening up new pathways for evolution.

NATURE (2022)

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Article Multidisciplinary Sciences

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

Huiping Shuai et al.

Summary: The Omicron variant of SARS-CoV-2 shows reduced replication ability in human cells and attenuated pathogenicity in mice compared with the wild-type strain and other variants. It has lower efficiency in using TMPRSS2 and causes the lowest reduction in body weight and mortality rate among the tested strains.

NATURE (2022)

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Article Multidisciplinary Sciences

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

Akatsuki Saito et al.

Summary: During the COVID-19 pandemic, the B.1.617.2/Delta variant has been found to be highly fusogenic and more pathogenic in infected hamsters compared to prototypic SARS-CoV-2. The P681R mutation in the spike protein of this variant enhances viral fusogenicity and pathogenicity.

NATURE (2022)

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News Item Multidisciplinary Sciences

FIRST PIG-TO-HUMAN HEART TRANSPLANT: WHAT CAN SCIENTISTS LEARN?

Sara Reardon

NATURE (2022)

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Article Multidisciplinary Sciences

Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer

Suresh V. Kuchipudi et al.

Summary: White-tailed deer, particularly in Iowa, have been found to be susceptible to SARS-CoV-2 infection and show evidence of human-to-deer transmission. This discovery highlights the need for a One Health approach to better understand the ecology, molecular evolution, and dissemination of the virus.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Infectious Diseases

First evidence of human-to-dog transmission of SARS-CoV-2 B.1.160 variant in France

Hacene Medkour et al.

Summary: This study reports a case of COVID-19 in a French dog living in close contact with its owners who were COVID-19 patients. The dog tested positive for SARS-CoV-2, with whole-genome sequences identical to its owners and matching the B.1.160 variant of concern. This highlights the potential role of pets in SARS-CoV-2 outbreaks and the risk of transmission to humans, particularly with the Marseille-4 variant.

TRANSBOUNDARY AND EMERGING DISEASES (2022)

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Letter Immunology

Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands

Reina S. Sikkema et al.

Summary: By combining the results of experimental and observational studies, it was determined that SARS-CoV-2 infection, transmission, and reservoir development in swine are unlikely to occur on a large scale. Sporadic infections may not be excluded entirely, but serological evidence for widespread transmission was not observed.

EMERGING MICROBES & INFECTIONS (2022)

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Article Immunology

Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant

Natasha N. Gaudreault et al.

Summary: This study investigated the susceptibility of sheep to SARS-CoV-2 through in vitro and in vivo experiments. The results showed that sheep have low susceptibility to SARS-CoV-2 infection, with limited viral RNA shedding and transmission efficiency. The study also found that the alpha variant outcompeted the lineage A strain in sheep.

EMERGING MICROBES & INFECTIONS (2022)

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Article Pathology

Natural SARS-CoV-2 Infection in a Free-Ranging Black-Tailed Marmoset (Mico melanurus) from an Urban Area in Mid-West Brazil

Asheley H. B. Pereira et al.

Summary: This study reports the first case of natural SARS-CoV-2 infection in a New World monkey, a free-ranging adult female black-tailed marmoset. Pathological examination revealed the presence of viral proteins in the lungs, liver, spleen, lymph nodes, and large intestine.

JOURNAL OF COMPARATIVE PATHOLOGY (2022)

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Article Medicine, General & Internal

Transmission of SARS-CoV-2 delta variant (AY.127) from pet hamsters to humans, leading to onward human-to-human transmission: a case study

Hui-Ling Yen et al.

LANCET (2022)

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Article Medicine, General & Internal

Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis

Ryan M. Barber et al.

Summary: Timely, accurate, and comprehensive estimation of SARS-CoV-2 infection rates are crucial for understanding past infections and transmission risks. This study provided a novel approach to estimate global and location-specific infections, combining data sources and correcting biases for more reliable estimates. The findings show staggering impacts of COVID-19 on the global population, highlighting the importance of continued research and policy responses.

LANCET (2022)

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News Item Multidisciplinary Sciences

COULD DEER BECOME A NATURAL COVID RESERVOIR?

Smriti Mallapaty

NATURE (2022)

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Article Virology

Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory Tract

Iris Faerber et al.

Summary: Several animal species have been found to be susceptible to SARS-CoV-2 infection, but the susceptibility of many species remains unknown. This study investigated the susceptibility of different animal species to SARS-CoV-2 by using primary cell cultures from their respiratory tracts. The study also examined the expression patterns of SARS-CoV-2 entry factors in the respiratory tracts of these animals. The results showed that dogs and hamsters were susceptible to infection, while ferrets and ungulate species were not.

VIRUSES-BASEL (2022)

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Article Veterinary Sciences

The Finding of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in a Wild Eurasian River Otter (Lutra lutra) Highlights the Need for Viral Surveillance in Wild Mustelids

Miguel Padilla-Blanco et al.

Summary: Animals have been involved in three outbreaks of severe respiratory syndromes caused by coronaviruses. The pandemic nature of the SARS-CoV-2 outbreak increases the risk of infection in susceptible animal species, potentially making them secondary hosts and reservoirs of the disease. In this study, evidence of spillover infection of a Eurasian river otter with SARS-CoV-2 was found in Spain. Genetic sequencing revealed some unique changes in the virus, suggesting a human origin. These findings emphasize the need for surveillance of wild or feral mustelids to assess their potential role as reservoirs of SARS-CoV-2.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Article Public, Environmental & Occupational Health

Striking lineage diversity of severe acute respiratory syndrome coronavirus 2 from non-human sources

Marina Munoz et al.

Summary: This study analyzed the diversity of viral genomes from non-human sources, identifying 128 lineages from 3595 publicly available SARS-CoV-2 genome sequences, with Delta and Alpha variants being the majority. Environmental sources, minks, white-tailed deer, and cats had the highest number of lineages. Further investigation into bat and pangolin genomes revealed five distinct clusters, one of which exclusively included bat-sourced genomes. These findings provide new genetic landmarks of SARS-CoV-2 evolution and suggest potential interspecies transmission routes between animals and humans.

ONE HEALTH (2022)

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Article Multidisciplinary Sciences

The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2

Jonathan E. Pekar et al.

Summary: Understanding the circumstances that lead to pandemics is crucial for their prevention. In this study, the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic was analyzed. The results suggest that before February 2020, SARS-CoV-2 likely consisted of two distinct viral lineages, labeled A and B. Through phylodynamic rooting methods and epidemic simulations, it was revealed that these lineages were the result of at least two separate cross-species transmission events into humans. The findings indicate that widespread circulation of SARS-CoV-2 in humans before November 2019 is unlikely, and define the narrow time window between the first jump of SARS-CoV-2 into humans and the first reported cases of COVID-19.

SCIENCE (2022)

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Article Multidisciplinary Sciences

The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

Michael Worobey et al.

Summary: This article demonstrates that the SARS-CoV-2 virus originated from the Huanan Seafood Wholesale Market in Wuhan, China, where susceptible animals were sold in late 2019, and SARS-CoV-2-positive environmental samples were spatially associated with vendors selling live animals.

SCIENCE (2022)

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Article Immunology

Suspected Cat-to-Human Transmission of SARS-CoV-2, Thailand, July-September 2021

Thanit Sila et al.

Summary: A veterinarian in Thailand was diagnosed with COVID-19 after being sneezed on by an infected cat, supporting the hypothesis of SARS-CoV-2 transmission from the owner to the cat and then from the cat to the veterinarian.

EMERGING INFECTIOUS DISEASES (2022)

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Article Multidisciplinary Sciences

Spike mutation D614G alters SARS-CoV-2 fitness

Jessica A. Plante et al.

Summary: The D614G substitution in the SARS-CoV-2 spike protein enhances viral replication and infectivity in human lung epithelial cells, primary airway tissues, and hamsters. This variant may increase transmission in the upper respiratory tract and doesn't seem to significantly reduce vaccine efficacy. Further research on therapeutic antibodies targeting the circulating G614 virus is recommended.

NATURE (2021)

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Article Infectious Diseases

Pigs are not susceptible to SARS-CoV-2 infection but are a model for viral immunogenicity studies

Julia Vergara-Alert et al.

Summary: Although piglets were not susceptible to SARS-CoV-2 and did not show viral RNA in tissues/swabs, seroconversion was observed in pigs inoculated parenterally (intramuscularly or intravenously).

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Article Infectious Diseases

Detection of SARS-CoV-2 in pets living with COVID-19 owners diagnosed during the COVID-19 lockdown in Spain: A case of an asymptomatic cat with SARS-CoV-2 in Europe

Ignacio Ruiz-Arrondo et al.

Summary: This study suggests that pets can potentially contract the virus from their COVID-19 infected owners, with cats possibly acting as hosts for SARS-CoV-2. Further investigation is needed to understand their role in carrying and disseminating the virus.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Review Allergy

Antibody therapy for COVID-19

Lennart Hammarstrom et al.

Summary: Antibody therapy for COVID-19 patients has shown great potential, especially with the use of monoclonal antibodies early in the disease process. Combining IgG monoclonal antibodies against the spike protein's receptor-binding domain appears to be the most effective form of antibody therapy, with promising results also seen with Immunoglobulin A dimers and Immunoglobulin M pentamers.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Immunology

High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2

Bernard Vanhove et al.

Summary: Heterologous polyclonal antibodies offer a potential alternative in COVID-19 treatment, but may trigger human xenogeneic antibody responses. A recent study introduced a method to produce glyco-humanized polyclonal antibodies that showed promising results in neutralizing the virus, highlighting the importance of further clinical assessment.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Article Virology

Susceptibility of White-Tailed Deer (Odocoileus virginianus) to SARS-CoV-2

Mitchell Palmer et al.

Summary: White-tailed deer are highly susceptible to infection by SARS-CoV-2, shedding infectious virus and transmitting it to other deer upon intranasal inoculation, providing important insights into the potential animal hosts of the virus.

JOURNAL OF VIROLOGY (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 spike D614G change enhances replication and transmission

Bin Zhou et al.

Summary: Research has shown that the D614G substitution in the spike protein of SARS-CoV-2 leads to increased binding and replication potential in humans, as well as significantly higher replication and transmissibility in different animal models, providing an explanation for the global prevalence of this variant in the COVID-19 pandemic.

NATURE (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Constantinos Kurt Wibmer et al.

Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2

Yinghui Liu et al.

Summary: Epidemiological studies have shown that bats are the natural reservoir of SARS-CoV-2, but the host range and intermediate hosts for transmission are unknown. This study characterized the ability of ACE2 from various species to support viral entry, suggesting a potentially broad host tropism of SARS-CoV-2. Analysis of ACE2 orthologs revealed that New World monkey ACE2 could not support viral entry, with genetic determinants restricting this interaction.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biology

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

Zharko Daniloski et al.

Summary: A novel variant of SARS-CoV-2 virus with mutation D614G has been found to be more effective at transducing human cells and showing increased infectivity in human cells compared to the wild-type variant.

ELIFE (2021)

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Article Gastroenterology & Hepatology

Low immunogenicity to SARS-CoV-2 vaccination among liver transplant recipients

Liane Rabinowich et al.

Summary: Liver transplant recipients showed significantly lower immunological response to the Pfizer-BioNTech SARS-CoV-2 mRNA-based vaccine, with less than half developing sufficient levels of antibodies and lower average antibody levels compared to healthy controls. Predictors for non-response included older age, renal function and immunosuppressive medications.

JOURNAL OF HEPATOLOGY (2021)

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Article Biology

Estimating the reproductive number R0 of SARS-CoV-2 in the United States and eight European countries and implications for vaccination

Ruian Ke et al.

Summary: The rapid spread of SARS-CoV-2 from a regional outbreak to a global pandemic necessitated high levels of intervention efforts to mitigate or contain the exponential epidemic growth. The early epidemic grew at exponential rates between 0.18 and 0.29/day, emphasizing the importance of effective control measures.

JOURNAL OF THEORETICAL BIOLOGY (2021)

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Article Cell Biology

Enhanced apoptosis as a possible mechanism to self-limit SARS-CoV-2 replication in porcine primary respiratory epithelial cells in contrast to human cells

Rahul K. Nelli et al.

Summary: The study investigated the susceptibility of species-specific cells to SARS-CoV-2, revealing that the virus could infect and replicate in both human and porcine respiratory epithelial cells in a dose-dependent manner. The findings suggested a possible mechanism of resistance of pigs to SARS-CoV-2 infection, which could have therapeutic implications for COVID-19 treatment.

CELL DEATH DISCOVERY (2021)

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Article Agriculture, Dairy & Animal Science

First Description of SARS-CoV-2 Infection in Two Feral American Mink (Neovison vison) Caught in the Wild

Jordi Aguilo-Gisbert et al.

Summary: COVID-19 is a significant pandemic likely of animal origin, with mink being highly susceptible to SARS-CoV-2 infection. The detection of SARS-CoV-2 in feral American mink in Eastern Spain suggests potential transmission pathways between fur farms and wild mink.

ANIMALS (2021)

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Review Biochemistry & Molecular Biology

The origins of SARS-CoV-2: A critical review

Edward C. Holmes et al.

Summary: This article critically reviews the current scientific evidence to help clarify the origin of SARS-CoV-2. Recent debate has centered around two competing ideas: a laboratory escape scenario and zoonotic emergence.

CELL (2021)

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Article Biochemistry & Molecular Biology

Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin

Sheng Niu et al.

Summary: The study found that the RBDs of pangolin coronaviruses can bind to human ACE2, allowing entry of pseudotyped VSV particles into cells expressing ACE2, suggesting potential infectivity of these two pangolin coronaviruses in humans. Additionally, their ACE2 binding modes are similar to SARS-CoV-2, with a broader host range than SARS-CoV-2, indicating the need for further monitoring of pangolin coronaviruses.

EMBO JOURNAL (2021)

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Article Virology

Intravenous, Intratracheal, and Intranasal Inoculation of Swine with SARS-CoV-2

Alexandra Buckley et al.

Summary: Research has shown that pigs cannot replicate or transmit the SARS-CoV-2 virus, indicating that they are unlikely to play a role in the epidemiology and spread of the virus.

VIRUSES-BASEL (2021)

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Article Virology

Clinical and Histopathologic Features of a Feline SARS-CoV-2 Infection Model Are Analogous to Acute COVID-19 in Humans

Jennifer M. Rudd et al.

Summary: The study demonstrates that intratracheal infection of specific-pathogen-free domestic cats with SARS-CoV-2 produced clinical disease and histopathologic lesions consistent with acute COVID-19 in humans. This validates the feline model for SARS-CoV-2 infection and encourages its use in future translational studies.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection and transmission in the North American deer mouse

Bryan D. Griffin et al.

Summary: The study demonstrates that North American deer mice are susceptible to SARS-CoV-2 infection and can replicate and transmit the virus without showing significant symptoms.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19

Hefziba Green et al.

Summary: The burden of COVID-19 on hospitals is significant globally, with clinical and economic implications. This study aimed to identify post-discharge outcomes and risk factors for re-admission among COVID-19 hospitalized patients, finding that re-admission rates are moderate and predictors are non-modifiable, such as baseline comorbidities. Post discharge mortality cases tend to be older with cognitive decline or ADL assistance needs.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin

Sakshi Piplani et al.

Summary: The study found that the spike protein of SARS-CoV-2 had the highest binding affinity to human ACE2, with pangolin ACE2 showing the next highest despite lower sequence homology and monkey ACE2 having much lower affinity despite high sequence similarity to human ACE2. Species with ACE2 in the upper half of predicted affinity range were found to be permissive to SARS-CoV-2 infection, suggesting a correlation between binding affinity and infection susceptibility. These findings suggest that the early SARS-CoV-2 isolates were well adapted to bind strongly to human ACE2, facilitating efficient human-to-human transmission and demonstrating the usefulness of in silico structural modelling methods in predicting virus behavior and aiding in countermeasure development.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

Rana Abdelnabi et al.

Summary: The global COVID-19 pandemic has resulted in over 108 million infections and 2.4 million deaths within a year, with new variants of concern emerging. Research on prototypic VoC from B.1.1.7 and B.1.351 variants in hamsters revealed efficient infection of the lower respiratory tract and highlighted the need for assessing vaccine and therapeutic efficacy against these variants.

EBIOMEDICINE (2021)

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Letter Cell Biology

Establishment of a humanized swine model for COVID-19

Xuguang Du et al.

CELL DISCOVERY (2021)

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Article Microbiology

Investigating the Presence of SARS CoV-2 in Free-Living and Captive Animals

Lorena Jemersic et al.

Summary: After testing dominant free-living and captive wildlife species in Croatia for anti-SARS CoV-2 antibodies and viral RNA, there was no evidence of animal infection. Further investigation is needed, especially regarding the impact of wildlife sample features on serological testing.

PATHOGENS (2021)

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Article Immunology

XAV-19, a Swine Glyco-Humanized Polyclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Domain, Targets Multiple Epitopes and Broadly Neutralizes Variants

Bernard Vanhove et al.

Summary: Amino acid substitutions and deletions in the Spike protein of SARS-CoV-2 variants can reduce the effectiveness of monoclonal antibodies, while polyclonal antibodies like XAV-19 show potential for maintaining neutralization capacities by targeting multiple epitopes. XAV-19, a swine glyco-humanized polyclonal neutralizing antibody, demonstrates potent neutralization capacities against different variants of SARS-CoV-2, covering various epitopes on the RBD region. Ongoing clinical trials are evaluating the efficacy and safety of XAV-19 in COVID-19 patients with promising results.

FRONTIERS IN IMMUNOLOGY (2021)

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Letter Immunology

Susceptibility of livestock to SARS-CoV-2 infection

Angela M. Bosco-Lauth et al.

Summary: Pilot studies showed that common domestic livestock infected with SARS-CoV-2 did not shed infectious virus and had low or non-existent neutralizing antibody titres one month post-infection. This suggests that domestic livestock are unlikely to contribute to the epidemiology of SARS-CoV-2.

EMERGING MICROBES & INFECTIONS (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 exposure in wild white-tailed deer (Odocoileus virginianus)

Jeffrey C. Chandler et al.

Summary: Research indicates that white-tailed deer in the United States have been exposed to SARS-CoV-2, with 40% of samples testing positive for antibodies. This suggests that human infections of the novel coronavirus may have an impact on wildlife.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Letter Veterinary Sciences

SARS-CoV-2 in animals: what about the cat?

Ana Izabel Passarella Teixeira

VETERINARY QUARTERLY (2021)

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Article Immunology

Experimental SARS-CoV-2 Infection of Bank Voles

Lorenz Ulrich et al.

Summary: Bank voles were experimentally infected with SARS-CoV-2, showing seroconversion within 8 days and viral RNA detection in nasal tissue up to 21 days. However, transmission to contact animals was not observed, indicating that bank voles are unlikely to establish effective transmission cycles in nature.

EMERGING INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans

Bas B. Oude Munnink et al.

Summary: Animal experiments have shown that various animals can be infected by SARS-CoV-2, with evidence of animal-to-human transmission within mink farms. Investigation into mink farm outbreaks revealed that the virus was initially introduced by humans and has since evolved, causing transmission between mink farms. Despite enhanced biosecurity measures and culling, transmission occurred between farms in three large clusters with unknown modes of transmission, resulting in a high percentage of infections among mink farm residents and employees.

SCIENCE (2021)

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Review Immunology

Comparison of the immunogenicity & protective efficacy of various SARS-CoV-2 vaccine candidates in non-human primates

Labanya Mukhopadhyay et al.

Summary: This systematic review compared the immunogenicity and protective efficacy of various SARS-CoV-2 vaccine candidates tested in non-human primate (NHP) models. Results showed that most vaccines induced detectable neutralizing antibodies and had some effectiveness in viral clearance. Some vaccines demonstrated better immunogenicity and protective efficacy in NHP models compared to others.

INDIAN JOURNAL OF MEDICAL RESEARCH (2021)

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Article Immunology

Susceptibility of Domestic Swine to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2

Brad S. Pickering et al.

Summary: Pigs are susceptible to SARS-CoV-2 with viral RNA and antibodies detected, but live virus was isolated from only one pig. Additional assessment of other livestock is needed to determine their potential role in the SARS-CoV-2 pandemic.

EMERGING INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

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Article Microbiology

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Young-Il Kim et al.

CELL HOST & MICROBE (2020)

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Article Microbiology

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

Shi-Hui Sun et al.

CELL HOST & MICROBE (2020)

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Article Biochemistry & Molecular Biology

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

Tao Zhang et al.

CURRENT BIOLOGY (2020)

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Article Multidisciplinary Sciences

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2

Jianzhong Shi et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sin Fun Sia et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Infection of dogs with SARS-CoV-2

Thomas H. C. Sit et al.

NATURE (2020)

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Article Multidisciplinary Sciences

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Linlin Bao et al.

NATURE (2020)

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Article Immunology

ACE2, Much More Than Just a Receptor for SARS-COV-2

Lobelia Samavati et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Biochemistry & Molecular Biology

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

Sarah R. Leist et al.

CELL (2020)

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Article Multidisciplinary Sciences

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Noe B. Mercado et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

Masaki Imai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Infectious Diseases

First detection and genome sequencing of SARS-CoV-2 in an infected cat in France

Corinne Sailleau et al.

TRANSBOUNDARY AND EMERGING DISEASES (2020)

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Article Microbiology

From People to Panthera: Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo

Denise McAloose et al.

MBIO (2020)

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Article Multidisciplinary Sciences

Susceptibility of tree shrew to SARS-CoV-2 infection

Yuan Zhao et al.

SCIENTIFIC REPORTS (2020)

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Article Multidisciplinary Sciences

Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

E. Patterson et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

Lizhou Zhang et al.

NATURE COMMUNICATIONS (2020)

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Letter Immunology

SARS-CoV-2 Natural Transmission from Human to Cat, Belgium, March 2020

Mutien Garigliany et al.

EMERGING INFECTIOUS DISEASES (2020)

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Article Immunology

Susceptibility of Raccoon Dogs for Experimental SARS-CoV-2 Infection

Conrad M. Freuling et al.

EMERGING INFECTIOUS DISEASES (2020)

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Letter Immunology

Lack of Susceptibility to SARS-CoV-2 and MERS-CoV in Poultry

David L. Suarez et al.

EMERGING INFECTIOUS DISEASES (2020)

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