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Victoria C. Cogger et al.
JOURNAL OF STRUCTURAL BIOLOGY (2010)
Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo
Maria B. Laursen et al.
MOLECULAR BIOSYSTEMS (2010)
Rational design of cationic lipids for siRNA delivery
Sean C. Semple et al.
NATURE BIOTECHNOLOGY (2010)
A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma
Agop Y. Bedikian et al.
MELANOMA RESEARCH (2010)
Lipid-like materials for low-dose, in vivo gene silencing
Kevin T. Love et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Sequence determinants of innate immune activation by short interfering RNAs
Amber Goodchild et al.
BMC IMMUNOLOGY (2009)
Physical methods of nucleic acid transfer: general concepts and applications
Julien Villemejane et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation
J. Zhou et al.
CANCER GENE THERAPY (2009)
Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs
Lasse Weinmann et al.
CELL (2009)
Origins and Mechanisms of miRNAs and siRNAs
Richard W. Carthew et al.
CELL (2009)
Advances in gene delivery through molecular design of cationic lipids
Santanu Bhattacharya et al.
CHEMICAL COMMUNICATIONS (2009)
Nonviral Vectors for Gene Delivery
Meredith A. Mintzer et al.
CHEMICAL REVIEWS (2009)
Progress and Prospects: The design and production of plasmid vectors
D. R. Gill et al.
GENE THERAPY (2009)
Intratumoral Epidermal Growth Factor Receptor Antisense DNA Therapy in Head and Neck Cancer: First Human Application and Potential Antitumor Mechanisms
Stephen Y. Lai et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Many roads to maturity: microRNA biogenesis pathways and their regulation
Julia Winter et al.
NATURE CELL BIOLOGY (2009)
Knocking down barriers: advances in siRNA delivery
Kathryn A. Whitehead et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
Jesper B. Bramsen et al.
NUCLEIC ACIDS RESEARCH (2009)
Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival
Y-P Sher et al.
ONCOGENE (2009)
Conventional and Dense Gas Techniques for the Production of Liposomes: A Review
Louise A. Meure et al.
AAPS PHARMSCITECH (2008)
Synthesis of 2 '-O-modified adenosine building blocks and application for RNA interference
Dalibor Odadzic et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Progress in Cationic Lipid-Mediated Gene Transfection: A Series of Bio-Inspired Lipids as an Example
Tristan Montier et al.
CURRENT GENE THERAPY (2008)
Cell-specific nuclear import of plasmid DNA in smooth muscle requires tissue-specific transcription factors and DNA sequences
A. M. Miller et al.
GENE THERAPY (2008)
Pharmacokinetics and biodistribution of nanoparticles
Shyh-Dar Li et al.
MOLECULAR PHARMACEUTICS (2008)
Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
Katalin Kariko et al.
MOLECULAR THERAPY (2008)
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
Stephen C. Hyde et al.
NATURE BIOTECHNOLOGY (2008)
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
Yasushi Sato et al.
NATURE BIOTECHNOLOGY (2008)
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akin Akinc et al.
NATURE BIOTECHNOLOGY (2008)
Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
Kumiko Ui-Tei et al.
NUCLEIC ACIDS RESEARCH (2008)
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
Maria Frank-Kamenetsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Renal clearance of quantum dots
Hak Soo Choi et al.
NATURE BIOTECHNOLOGY (2007)
Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models
Xiaoming Xie et al.
CANCER CELL (2007)
Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I
Soo In Kim et al.
MOLECULAR THERAPY (2007)
Gene expression analysis in blood cells in response to unmodified and 2′-modified siRNAs reveals TLR-dependent and independent effects
Lina Cekaite et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
A protocol for designing siRNAs with high functionality and specificity
Amanda Birmingham et al.
NATURE PROTOCOLS (2007)
Nonviral delivery vehicles for use in short hairpin RNA-based cancer therapies
John S. Vorhies et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2007)
Lipid-based nanoparticles for nucleic acid delivery
Weijun Li et al.
PHARMACEUTICAL RESEARCH (2007)
Phase 2 trial of Allovectin-7 in advanced metastatic melanoma
Rene Gonzalez et al.
MELANOMA RESEARCH (2006)
Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines
Keith K. B. Gorden et al.
JOURNAL OF IMMUNOLOGY (2006)
Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides
Sandra S. Diebold et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2006)
Vector-based RNAi approaches for stable, inducible and genome-wide screens
Gwen D. Fewell et al.
DRUG DISCOVERY TODAY (2006)
Cubic phases in phosphatidylcholine-cholesterol mixtures: Cholesterol as membrane fusogen''
Boris G. Tenchov et al.
BIOPHYSICAL JOURNAL (2006)
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
A. Santel et al.
GENE THERAPY (2006)
Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery
Marc Antoniu Ilies et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Development and in vitro validation of a targeted delivery vehicle for DNA vaccines
Silke S. Talsma et al.
JOURNAL OF CONTROLLED RELEASE (2006)
RNAi-mediated gene silencing in non-human primates
TS Zimmermann et al.
NATURE (2006)
Antisense oligonucleotides: From design to therapeutic application
JHP Chan et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2006)
Use of lipoplex-induced nuclear factor-kappa B activation to enhance transgene expression by lipoplex in mouse tung
T Kuramoto et al.
JOURNAL OF GENE MEDICINE (2006)
Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors
K Kostarelos et al.
CHEMICAL SOCIETY REVIEWS (2005)
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
J Heyes et al.
JOURNAL OF CONTROLLED RELEASE (2005)
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
DV Morrissey et al.
NATURE BIOTECHNOLOGY (2005)
Suppression of RNA recognition by Toll-like receptors:: The impact of nucleoside modification and the evolutionary origin of RNA
K Karikó et al.
IMMUNITY (2005)
The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse
XD Yan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic acid
SC Semple et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Combination nonviral interleukin-2 gene immunotherapy for head and neck cancer: From bench top to bedside
BW O'Malley et al.
LARYNGOSCOPE (2005)
Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener
MA Ilies et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
V Hornung et al.
NATURE MEDICINE (2005)
DNA-based therapeutics and DNA delivery systems: A comprehensive review
SD Patil et al.
AAPS JOURNAL (2005)
Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs
HJ Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
DNA double-strand break repair by homologous recombination
A Dudás et al.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2004)
PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase
F Leenders et al.
EMBO JOURNAL (2004)
Pyridinium cationic lipids in gene delivery: A structure-activity correlation study
MA Ilies et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Nanoparticle based systemic gene therapy for lung cancer: Molecular mechanisms and strategies to suppress nanoparticle-mediated inflammatory response
B Gopalan et al.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2004)
Intratumoral administration of a 1,2-dimyristyloxypropyl-3-dimethylhydroxyethyl ammonium bromide/dioleoylphosphatidylethanolamine formulation of the human interleukin-2 gene in the treatment of metastatic renal cell carcinoma
E Galanis et al.
CANCER (2004)
DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta potential measurements and electron spin resonance spectra
L Ciani et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)
RNA interference using boranophosphate siRNAs: structure-activity relationships
AHS Hall et al.
NUCLEIC ACIDS RESEARCH (2004)
Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy
SM Thomas et al.
CANCER GENE THERAPY (2003)
Antisense technologies - Improvement through novel chemical modifications
J Kurreck
EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Gemini surfactants: New synthetic vectors for gene transfection
AJ Kirby et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain
HL Fitzsimons et al.
METHODS (2002)
Non-viral gene delivery systems
ME Davis
CURRENT OPINION IN BIOTECHNOLOGY (2002)
Cationic lipids in gene delivery: Principles, vector design and therapeutical applications
MA Ilies et al.
CURRENT PHARMACEUTICAL DESIGN (2002)
Systemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFv
L Xu et al.
MOLECULAR MEDICINE (2001)
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
IM Hafez et al.
GENE THERAPY (2001)
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
SM Elbashir et al.
NATURE (2001)
Nonviral vectors in the new millennium: Delivery barriers in gene transfer
M Nishikawa et al.
HUMAN GENE THERAPY (2001)
A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis
FE Ruiz et al.
HUMAN GENE THERAPY (2001)
Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector
R Ramesh et al.
MOLECULAR THERAPY (2001)
Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis
SC Hyde et al.
GENE THERAPY (2000)
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
C Wahlestedt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Intratumoral interleukin 2 for renal-cell carcinoma by direct gene transfer of a plasmid DNA/DMRIE/DOPE lipid complex
DMJ Hoffman et al.
WORLD JOURNAL OF UROLOGY (2000)
Optimization of cationic lipid/DNA complexes for systemic gene transfer to tumor lesions
K Anwer et al.
JOURNAL OF DRUG TARGETING (2000)
Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis
PG Noone et al.
MOLECULAR THERAPY (2000)
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