期刊
WATER RESEARCH
卷 226, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.watres.2022.119275
关键词
Ambroxol; 4-dibromoaniline; Debromination; Photodegradation; Photolysis mechanisms; Photoproducts
资金
- Na-tional Natural Science Foundation of China
- [22076080]
Ambroxol (AMB) is an effective expectorant drug commonly used to treat bronchitis. However, the extensive use and excretion of AMB by humans lead to its widespread occurrence in wastewater. This study investigates the photolysis of AMB in aqueous solution under 254 nm ultraviolet radiation (UV254). The results show that AMB undergoes complex photoreactions, including photoreduction, photoionization, photonucleophilic substitution, side-chain cleavage, and coupling reactions. UV254 radiation effectively degrades AMB in wastewater, but caution should be exercised when treating wastewater with high concentrations of AMB due to the potential formation of toxic byproducts.
As one of the most effective expectorant class drugs, ambroxol (AMB) has been frequently used to treat acute and chronic bronchitis. Extensive use and human excretion result in the widespread occurrence of AMB in waste-water. Herein, we reported the photolysis of AMB in aqueous solution upon 254 nm ultraviolet radiation (UV254). Spectroscopic characterization showed that 2,4-dibromoaniline (DBA) moiety is the core chromophore of AMB. Quantum yield of DBA changed little at pH 4.0 -9.0; however, AMB showed higher quantum yield at pH > 8.0. Both DBA and AMB have high photoreactivity, which can be attributed to the heavy atom effect of bromine substituents. The photolysis of AMB occurred through photoreduction, photoionization, photonucleophilic substitution, side-chain cleavage, and coupling reactions. Both AMB and DBA underwent debromination with yields reaching 80% under 3200 mJ cm-2 UV fluence. Photo-debromination occurred preferentially at the para- position. The presence of natural organic matter inhibited the photodegradation, mainly due to the light -screening effect. The photolysis of AMB was slightly enhanced in the presence of NO3- likely due to radical -induced oxidation. Bioluminescence inhibition assay revealed that photoproducts were not toxic. The results show that UV254 radiation with fluences relevant to advanced oxidation processes was effective for the abate-ment of AMB in wastewater. However, UV254 treatment of wastewater containing higher concentrations (> mu g L-1) of AMB should be done with caution because the released Br- can be converted to toxic brominated disinfection byproducts and bromate in subsequent oxidation process.
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