期刊
VETERINARY PATHOLOGY
卷 60, 期 1, 页码 69-74出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/03009858221133506
关键词
endometritis; goat; metritis; Paeniclostridium sordellii; uterus
This study investigated the association of P. sordellii with veterinary reproductive disease in goats. The retrospective search of a database identified 9 cases of goats with P. sordellii-associated metritis or endometritis, often co-colonized by Escherichia coli. The presence of copper deficiency in some cases suggests a possible influencing factor. This is the first report documenting the association of P. sordellii with veterinary gynecological disease.
Paeniclostridium sordellii is involved in enteric and histotoxic infections in several animal species. In humans, P. sordellii has been linked to gynecological disease, an association not previously investigated in animals. To unveil a potential association of P. sordellii with veterinary reproductive disease, a retrospective search of the database of the California Animal Health and Food Safety Laboratory System (1990-2020) was conducted and identified 9 cases of goats with P. sordellii-associated metritis or endometritis that were confirmed by immunofluorescence antibody test and/or bacterial isolation, and often co-colonized by Escherichia coli. Six of 9 does were also copper deficient. Polymerase chain reaction (PCR) on formalin-fixed, paraffin-embedded uterine tissue identified the sordellilysin gene in all 9 cases, and the lethal toxin gene in 4. Our findings suggest goats could be predisposed to P. sordellii-associated endometritis/metritis and toxemia when co-infected with E. coli. The role of mineral deficiencies influencing vulnerability to puerperal bacterial infections in goats is possible but remains undetermined. To our knowledge, this is the first report documenting the association of P. sordellii with veterinary gynecological disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据