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The pharmacology of the TMEM16A channel: therapeutic opportunities

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Polymodal Control of TMEM16x Channels and Scramblases

Emilio Agostinelli et al.

Summary: The TMEM16A/anoctamin-1 calcium-activated chloride channel plays a vital role in controlling vascular tone and epithelial ion transport. It is a founding member of a protein family with diverse functions, and its regulation is influenced by calcium signaling as well as various other cellular factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity

Sai Shi et al.

Summary: Lung cancer has the highest mortality rate among cancers worldwide and lacks effective treatments. Through screening of marketed drugs, we identified Zafirlukast (ZAF), a drug approved for asthma treatment, as an inhibitor of the TMEM16A channel. ZAF demonstrated the ability to inhibit the proliferation and migration of lung adenocarcinoma cells and showed promising results in mouse models. It represents a potential therapeutic option for lung adenocarcinoma.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Article Multidisciplinary Sciences

Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC

Andy K. M. Lam et al.

Summary: In this study, the authors used cryo-EM and electrophysiology to reveal the mechanism of TMEM16A inhibition by the pore blocker 1PBC. They found that 1PBC binds to a pocket located externally to the neck region of the channel, stabilizing an open-like conformation and affecting the gating mechanism. These findings provide important insights for the design of new and potent TMEM16A modulators.

NATURE COMMUNICATIONS (2022)

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Article Medicine, Research & Experimental

The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia

Nils Korte et al.

Summary: A small increase in cytoplasmic calcium concentration in pericytes activates chloride efflux through the TMEM16A channel, leading to depolarization of the cell and opening of voltage-gated calcium channels. Inhibition of TMEM16A slows down ischemia-induced increase in calcium concentration, reduces pericyte death, and improves cerebrovascular reperfusion in a rodent stroke model. Altered TMEM16A expression is implicated in poor patient recovery from ischemic stroke, suggesting its potential as a therapeutic target.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Review Cell Biology

Chloride transport modulators as drug candidates

Alan S. Verkman et al.

Summary: Chloride transport plays crucial roles in various physiological processes, and mutations in chloride transport proteins can lead to a range of diseases. While significant progress has been made in drug treatment for cystic fibrosis, other chloride channels and SLCs remain relatively underexplored as potential drug targets, despite their promising applications in treating diseases like secretory diarrhea and kidney stones.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes

M. Dennis Leo et al.

Summary: This study demonstrates the involvement of TMEM16A channels in vascular dysfunction during type 2 diabetes. Higher levels of TMEM16A message, protein, and currents were observed in smooth muscle cells of resistance-size arteries during T2D. Arteries from T2D mice showed increased vasoconstriction compared to non-diabetic mice, a response that was abolished in TMEM16A smKO mice. Additionally, a decrease in Akt2 function was found to stimulate TMEM16A expression in arterial smooth muscle cells, leading to vasoconstriction during T2D.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy

Xuan Zhang et al.

Summary: ANO1, a Ca2+-activated Cl- channel, plays important roles in physiological functions and tumor growth. Cepharanthine, identified as a potent blocker of ANO1 channels, inhibits cell proliferation and migration, induces apoptosis, and shows anticancer effects.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Pharmacology & Pharmacy

Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum

Zhijun Zhao et al.

Summary: In this study, evodiamine and rutecarpine extracted from Evodia rutaecarpa were identified as novel TMEM16A inhibitors with inhibitory effects on intestinal peristalsis. They suppressed TMEM16A Cl- currents and significantly decreased peristalsis in isolated guinea-pig ileum, supporting the regulatory effect of TMEM16A modulators on gastrointestinal motility.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

Yani Liu et al.

Summary: ANO1 gene encodes a Ca2+ activated Cl- channel critical for physiological functions, with abnormal expression or dysfunction linked to various diseases. The lack of specific modulators hinders the validation of ANO1 as a therapeutic target.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Physiology

Anoctamin 1 antagonism potentiates conventional tocolytic-mediated relaxation of pregnant human uterine smooth muscle

Shunsuke Hyuga et al.

Summary: This study aimed to determine the synergistic potency and mechanistic basis of two ANO1 antagonists with currently available tocolytic drugs. The combination of sub-threshold doses of ANO1 antagonists and tocolytic drugs demonstrated significant synergy in relaxing human pregnant USM compared to when administered individually. This may pave the way for novel tocolytic drug combinations.

JOURNAL OF PHYSIOLOGICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

TMEM16A Protein: Calcium-Binding Site and its Activation Mechanism

Wanying Ji et al.

Summary: This review discusses the calcium sensing sites and activation properties of TMEM16A, helping to understand the structure-function relationship of TMEM16A and providing insights for molecular design targeting the TMEM16A channel.

PROTEIN AND PEPTIDE LETTERS (2021)

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Article Multidisciplinary Sciences

Mechanism of pore opening in the calcium-activated chloride channel TMEM16A

Andy K. M. Lam et al.

Summary: The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.

NATURE COMMUNICATIONS (2021)

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Article Biology

Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels

Zhiguang Jia et al.

Summary: The study demonstrates that specific binding of PIP2 to TMEM16A can lead to spontaneous opening of the permeation pathway in the Ca2+-bound state, predicting an activated state consistent with mutagenesis and functional data. This provides a basis for understanding the interplay of multiple signals in controlling TMEM16A channel function.

COMMUNICATIONS BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Groovy TMEM16 Family: Molecular Mechanisms of Lipid Scrambling and Ion Conduction

Valeria Kalienkova et al.

Summary: The TMEM16 family of membrane proteins displays a remarkable functional dichotomy, with some members being Ca2+-activated anion channels and others being Ca2+-activated lipid scramblases. Recent studies show that the function and evolution of this family are regulated by a series of cellular factors, with surrounding membrane properties playing a crucial role.

JOURNAL OF MOLECULAR BIOLOGY (2021)

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Article Urology & Nephrology

A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats

Onur Cil et al.

Summary: Pharmacological inhibition of TMEM16A can effectively reduce blood pressure in vascular smooth muscle cells in vitro and produce significant effects in spontaneously hypertensive rats.

KIDNEY INTERNATIONAL (2021)

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Article Medicine, Research & Experimental

Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells

Pengmei Guo et al.

Summary: The study showed that enhanced activity of CaCCs in arterial smooth muscle cells and increased Ca2+ mobilization play a pivotal role in the distinctive hypercontractility of rat coronary arteries to acidosis, which may lead to a new approach in understanding and treating cardiac complications in severe acidosis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels

M. B. Hawn et al.

Summary: This article summarizes the functions and regulatory mechanisms of Ca2+-activated Cl- channels, focusing on recent studies on ANO1 and its regulation by internal Ca2+, membrane lipids, and protein partners. It also reviews the basic properties, historical controversies, and molecular structures of CaCCs.

CHANNELS (2021)

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Review Chemistry, Medicinal

Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

Junjie Zhong et al.

Summary: ANO1, also known as TMEM16A, is the molecular basis of calcium-activated chloride channels widely expressed in mammalian cells. It could be a potential new drug target for the treatment of cancer, pain, diarrhea, hypertension, and asthma.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Theaflavin binds to a druggable pocket of TMEM16A channel and inhibits lung adenocarcinoma cell viability

Sai Shi et al.

Summary: The study identified a highly effective TMEM16A inhibitor, theaflavin, which adopts a wedge insertion mode to block the ion conduction pore and induce pore closure. The experimental results confirmed the mechanism through which theaflavin binds to the specific binding pocket on TMEM16A, showing potential inhibitory effects on the growth and migration of lung adenocarcinoma cells.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Emerging Modulators of TMEM16A and Their Therapeutic Potential

Anqi Hao et al.

Summary: Calcium-activated chloride channels (CaCCs) rely on calcium activation to function, with TMEM16A identified as the molecular basis of CaCCs. TMEM16A is widely expressed in various cells and controls basic physiological functions, but abnormal function may lead to various diseases.

JOURNAL OF MEMBRANE BIOLOGY (2021)

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Article Multidisciplinary Sciences

An outer-pore gate modulates the pharmacology of the TMEM16A channel

Ria L. Dinsdale et al.

Summary: Research has found that TMEM16A channels are sensitive to the extracellular modulator A9C in the presence of intracellular Ca2+, but insensitive when intracellular Ca2+ is omitted. This conclusion highlights a critical site for pharmacological intervention and reveals an aspect of Ca2+ gating in the TMEM16A channel.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biophysics

The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A

Shuai Guo et al.

BIOPHYSICAL JOURNAL (2020)

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Article Critical Care Medicine

TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis

Henry L. Danahay et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Letter Critical Care Medicine

TMEM16A Potentiation: Possible Drawbacks

Andrea Olschewski et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Letter Critical Care Medicine

TMEM16A Potentiation: Possible Drawbacks Reply

Henry L. Danahay et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Review Biochemistry & Molecular Biology

TMEM16A: An Alternative Approach to Restoring Airway Anion Secretion in Cystic Fibrosis?

Henry Danahay et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Allosteric modulation of alternatively spliced Ca2+-activated Cl- channels TMEM16A by PI(4,5)P2 and CaMKII

Woori Ko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation

Son C. Le et al.

CELL REPORTS (2020)

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Article Biochemistry & Molecular Biology

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

Henry Danahay et al.

FASEB BIOADVANCES (2020)

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Article Pharmacology & Pharmacy

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Kent Miner et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension

Henry R. Askew Page et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Article Respiratory System

Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension

Rita Papp et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Biology

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

Carolina Alvadia et al.

ELIFE (2019)

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Article Biochemistry & Molecular Biology

Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A

Onur Cil et al.

FASEB JOURNAL (2019)

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Article Cell Biology

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

Shengjie Feng et al.

CELL REPORTS (2019)

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Review Cell Biology

The multifaceted role of TMEM16A in cancer

David Crottes et al.

CELL CALCIUM (2019)

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Article Multidisciplinary Sciences

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A)

Kuai Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Neurosciences

TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke

Pin-yi Liu et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Neurosciences

TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels

Michele Genovese et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

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Article Multidisciplinary Sciences

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

Son C. Le et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

K. Simon R. Bushell et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury

Qin-Yi Chen et al.

NEURAL REGENERATION RESEARCH (2019)

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Niclosamide repurposed for the treatment of inflammatory airway disease

Ines Cabrita et al.

JCI INSIGHT (2019)

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Review Physiology

Known structures and unknown mechanisms of TMEM16 scramblases and channels

Maria E. Falzone et al.

JOURNAL OF GENERAL PHYSIOLOGY (2018)

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Article Neurosciences

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel

Christian J. Peters et al.

NEURON (2018)

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Review Clinical Neurology

Targeting pericytes for therapeutic approaches to neurological disorders

Jinping Cheng et al.

ACTA NEUROPATHOLOGICA (2018)

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Article Biochemistry & Molecular Biology

Prediction of Novel Anoctamin1 (ANO1) Inhibitors Using 3D-QSAR Pharmacophore Modeling and Molecular Docking

Yoon Hyeok Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Biology

Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A

Andy K. M. Lam et al.

ELIFE (2018)

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Article Physiology

Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat real afferent arteriole

Kay-Pong Yip et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Chemistry, Medicinal

Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A)

Eric C. Truong et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Multidisciplinary Sciences

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

Cristina Paulino et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Shangyu Dang et al.

NATURE (2017)

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Article Physiology

Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal

Stephen Fedigan et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)

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Article Biology

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

Cristina Paulino et al.

ELIFE (2017)

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Article Pharmacology & Pharmacy

Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels

Chau M. Ta et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Review Endocrinology & Metabolism

Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline

Leif Ostergaard et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)

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Article Pharmacology & Pharmacy

Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker

Chau M. Ta et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Article Pharmacology & Pharmacy

Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours

Shenbin Liu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Article Physiology

Independent activation of distinct pores in dimeric TMEM16A channels

Grace Jeng et al.

JOURNAL OF GENERAL PHYSIOLOGY (2016)

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Article Physiology

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A

Novandy K. Lim et al.

JOURNAL OF GENERAL PHYSIOLOGY (2016)

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Review Neurosciences

Pericytes of the neurovascular unit: key functions and signaling pathways

Melanie D. Sweeney et al.

NATURE NEUROSCIENCE (2016)

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Review Physiology

Cellular functions of TMEM16/anoctamin

Uhtaek Oh et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2016)

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Review Physiology

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

Jarred M. Whitlock et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2016)

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Article Multidisciplinary Sciences

Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2

Yohan Seo et al.

PLOS ONE (2016)

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New selective inhibitors of calcium-activated chloride channels-T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit?

D. M. B. Boedtkjer et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

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Review Biochemistry & Molecular Biology

Establishment and Dysfunction of the Blood-Brain Barrier

Zhen Zhao et al.

CELL (2015)

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Article Cardiac & Cardiovascular Systems

Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl- channel, contributes to spontaneous hypertension

Bingxiang Wang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

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Review Physiology

Regulation of vascular tone and arterial blood pressure: role of chloride transport in vascular smooth muscle

Christian A. Huebner et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)

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Article Multidisciplinary Sciences

Clinical significance of Anoctamin-1 gene at 11q13 in the development and progression of head and neck squamous cell carcinomas

Juan P. Rodrigo et al.

SCIENTIFIC REPORTS (2015)

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Article Medicine, Research & Experimental

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure

Christoph Heinze et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Neurosciences

Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity

Byeongjun Lee et al.

MOLECULAR PAIN (2014)

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Article Multidisciplinary Sciences

Capillary pericytes regulate cerebral blood flow in health and disease

Catherine N. Hall et al.

NATURE (2014)

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Review Physiology

STRUCTURE AND FUNCTION OF TMEM16 PROTEINS (ANOCTAMINS)

Nicoletta Pedemonte et al.

PHYSIOLOGICAL REVIEWS (2014)

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Review Physiology

Cl- channels in smooth muscle cells

Simon Bulley et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)

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Article Biology

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

Jason Tien et al.

ELIFE (2014)

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Review Oncology

The Ca2+-activated Cl- channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

Zhiqiang Qu et al.

CANCER MEDICINE (2014)

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Article Multidisciplinary Sciences

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

Jinsei Jung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Pharmacology & Pharmacy

MONNA, a Potent and Selective Blocker for Transmembrane Protein with Unknown Function 16/Anoctamin-1

Soo-Jin Oh et al.

MOLECULAR PHARMACOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

Kuai Yu et al.

CIRCULATION RESEARCH (2012)

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Article Neurosciences

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

Hawon Cho et al.

NATURE NEUROSCIENCE (2012)

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Article Biochemistry & Molecular Biology

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

Wan Namkung et al.

FASEB JOURNAL (2011)

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Ca2+-Activated Cl- Channels

Loretta Ferrera et al.

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Role of epithelial HCO3- transport in mucin secretion: lessons from cystic fibrosis

Paul M. Quinton

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A new role for bicarbonate in mucus formation

Eric Y. T. Chen et al.

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Murine vasa recta pericyte chloride conductance is controlled by calcium, depolarization, and kinase activity

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The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels

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TMEM16A/Anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells

Boris Manoury et al.

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Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

Loretta Ferrera et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels

H. Criss Hartzell et al.

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Article Biochemistry & Molecular Biology

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

Muge Yemisci et al.

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Article Biochemistry & Molecular Biology

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit

Bjoern Christian Schroeder et al.

CELL (2008)

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TMEM16A confers receptor-activated calcium-dependent chloride conductance

Young Duk Yang et al.

NATURE (2008)

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Article Multidisciplinary Sciences

TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity

Antonella Caputo et al.

SCIENCE (2008)

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Lactoperoxidase and hydrogen peroxide metabolism in the airway

GE Conner et al.

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Abnormalities of endothelial function in the pathogenesis of stroke: The importance of endothelin

M Volpe et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2000)

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