期刊
TRENDS IN PARASITOLOGY
卷 38, 期 10, 页码 868-881出版社
CELL PRESS
DOI: 10.1016/j.pt.2022.08.002
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资金
- German Research Council (DFG)
- Robert Koch -Institute
- National Institutes of Health [R01 AI125534]
- Johns Hopkins Malaria Research Institute postdoctoral fellowship
- Johns Hopkins Malaria Research Institute
- Bloomberg Philanthropies
This article reviews the important contribution of ferredoxin in isoprenoid and lipoate biosynthesis as well as tRNA modification in the apicoplast, and discusses its potential role in the initial steps of FeS synthesis and recent evidence on NADPH generation in Plasmodium spp.
The apicoplast, a relict plastid found in most species of the phylum Apicomplexa, harbors the ferredoxin redox system which supplies electrons to enzymes of various metabolic pathways in this organelle. Recent reports in Toxoplasma gondii and Plasmodium falciparum have shown that the iron -sulfur cluster (FeS)-containing ferredoxin is essential in tachyzoite and blood -stage parasites, respectively. Here we review ferredoxin's crucial contribution to isoprenoid and lipoate biosynthesis as well as tRNA modification in the apicoplast, highlighting similarities and differences between the two species. We also discuss ferredoxin's potential role in the initial reductive steps required for FeS synthesis as well as recent evidence that offers an explanation for how NADPH required by the redox system might be generated in Plasmodium spp.
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