Two-step recognition of HIV-1 DNA in the cytosol

Retroviral DNA induces the production of interferons. A new study by Yoh et al. showed that the host factor PQBP1' primes immune recognition of retroviral DNA by recruiting the cytosolic DNA scavenger cGAS' to the HIV-1 capsid. Their findings support the importance of innate immune sensing in HIV-1 infection. cient detection ing early unclear. To address surrounding in their [3] showed protein capsid priming the receptor of

Automated summary

A new study by Yoh et al. revealed that the host factor PQBP1 enhances immune recognition of retroviral DNA by recruiting the cytosolic DNA scavenger cGAS to the HIV-1 capsid, leading to the production of interferons. These findings highlight the significance of innate immune sensing in HIV-1 infection.