Sterols in asthma

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

Automated summary

While sterols have a regulatory role in immune processes related to asthma, the use of statin drugs to inhibit sterols has yielded conflicting results in human asthma. This study highlights the potential relevance of sterols and statins in severe asthma endotypes characterized by neutrophil infiltration.